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Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson\u2019s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. <jats:italic>Objective<\/jats:italic>. To delineate NMS in FDR of patients with different clinical types of PD. <jats:italic>Methods<\/jats:italic>. A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types. <jats:italic>Results<\/jats:italic>. The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12\u201314.92; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.033<\/mml:mn><\/mml:mrow><\/mml:math>), anxiety (OR = 4.22; 95% CI: 1.87\u20139.52; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00\u201311.48; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.049<\/mml:mn><\/mml:mrow><\/mml:math>) than the FDR of late-onset PD (LOP). It was also found that RBD (OR = 11.65; 95% CI: 3.82\u201335.54; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), constipation (OR = 4.94; 95% CI: 1.85\u201313.21; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), sleep disorders (OR = 4.51; 95% CI: 1.73\u201311.78; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>), cognitive impairment (OR = 3.55; 95% CI: 1.62\u20137.77; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>), and anxiety (OR = 2.49; 95% CI: 1.32\u20134.71; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:mrow><\/mml:math>) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP). <jats:italic>Conclusions<\/jats:italic>. The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage. Whether they have a greater possibility to progress into PD requires further investigation.<\/jats:p>","DOI":"10.1155\/2019\/1654161","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T13:07:28Z","timestamp":1546434448000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-2846","authenticated-orcid":true,"given":"Jiang-bing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-0230","authenticated-orcid":true,"given":"Jun-ling","family":"Leng","sequence":"additional","affiliation":[{"name":"Emergency Department, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-7213","authenticated-orcid":true,"given":"Ying-ge","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-4614","authenticated-orcid":true,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie-yu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-9866","authenticated-orcid":true,"given":"Li-hong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3013-9842","authenticated-orcid":true,"given":"Xin-jiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-0219","authenticated-orcid":true,"given":"Chun-feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000894"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1831"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-006-0055-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22067"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.12.1385"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.10.1458"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(02)00065-9"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312279.49272.9f"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/wco.0000000000000349"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24051"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.03.021"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.4.jnp417"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26166"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp245"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000842"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.42.6.1142"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25383"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.03.025"},{"issue":"4","key":"20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1001\/jama.281.4.341","volume":"281","year":"1999","journal-title":"JAMA"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.12.054"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.105940"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100036635"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22032"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03167.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12461"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.09.001"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20061"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2003.07.006"},{"issue":"20","key":"30","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1001\/jama.283.20.2674","volume":"283","year":"2000","journal-title":"JAMA"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23297"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23178"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/81834"}],"container-title":["Parkinson's 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