{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:07:11Z","timestamp":1788671231350,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,12,16]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate ultrasonographically the salivary glands and to correlate ultrasonographic parameters with focus score, serum beta-2-microglobulin, and stimulated salivary flow rate. <jats:italic>Material and Methods<\/jats:italic>. 32 patients with primary Sj\u00f6gren\u2019s syndrome (pSS) and 32 healthy controls were enrolled in this case-control study, performed in the Department of Internal Medicine, Division of Rheumatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Timi\u0219oara, Romania. All the patients and controls were examined by salivary gland ultrasonography (B-mode, color and spectral Doppler, and sonoelastography), determining the following parameters: salivary gland ultrasonography (SGUS) score, resistive index (RI) of transverse facial artery, and shear wave velocity (SWV). Serum beta-2-microglobulin and stimulated saliva amount were determined in all the patients and controls. Minor salivary gland biopsy with focus score assessment was done in pSS patients. <jats:italic>Results<\/jats:italic>. Patients with pSS presented higher SGUS score and parotid and submandibular SWV and reduced RI of transverse facial artery than controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). In pSS patients, statistically significant correlations were identified between assessed ultrasonographic parameters and focus score, serum beta-2-microglobulin, and respective stimulated saliva flow (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. This study highlighted statistically significant correlations between salivary gland ultrasonographic parameters and focus score, serum beta-2-microglobulin, and stimulated saliva flow.<\/jats:p>","DOI":"10.1155\/2019\/1716848","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:30:43Z","timestamp":1576521043000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["The Utility of Major Salivary Gland Ultrasonographic Parameters in the Diagnosis of Sj\u00f6gren Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-425X","authenticated-orcid":true,"given":"Alexandru","family":"Caraba","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Corina","family":"Babalic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, City Hospital, Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stela","family":"Iurciuc","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Iurciuc","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"S165","volume":"36","year":"2018","journal-title":"Clinical and Experimental Rheumatology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"3","first-page":"1221","volume-title":"Sjogren's Syndrome","year":"2017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1148\/rg.263055024"},{"issue":"4","key":"5","first-page":"351","volume":"10","year":"1992","journal-title":"Clinical and Experimental Rheumatology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.02.003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/art.37698"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu238"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev385"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2016.03.008"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2014.08.021"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1397"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.01085"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2793898"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.891439"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2186\/prp.2.82"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210448"},{"key":"18","year":"2018"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-016-0112-0"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23707"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken222"},{"issue":"3","key":"22","first-page":"311","volume":"1","year":"2007","journal-title":"Biologics: Targets & Therapy"},{"issue":"5","key":"23","first-page":"1222","volume":"27","year":"2000","journal-title":"The Journal of Rheumatology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1586-9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2019.05.03"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3705-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.11.002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.11.009"},{"issue":"5","key":"29","first-page":"1229","volume":"27","year":"2000","journal-title":"The Journal of Rheumatology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2003.04.003"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev253"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12387"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162787"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211250"},{"issue":"1","key":"35","first-page":"56","volume":"33","year":"2015","journal-title":"Clinical and Experimental Rheumatology"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/1716848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/1716848.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2019\/1716848.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:30:48Z","timestamp":1576521048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2019\/1716848\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":35,"alternative-id":["1716848","1716848"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1716848","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]}}}