{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:12:54Z","timestamp":1782861174834,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,3,26]]},"abstract":"<jats:p>Cardiovascular diseases (CVD) constitute one of the most prevalent health problems worldwide, being strongly associated with metabolic syndrome (MS). Oxidative stress (OS) is present in both CVD and MS. Infusions of<jats:italic>Hibiscus sabdariffa Linnaeus<\/jats:italic>(HSL) have antioxidant properties and could therefore decrease the presence of OS in these diseases. The aim of this study was to evaluate myocardial protection during ischemia\/reperfusion due to the antioxidant effect of HSL infusion (3%) on a MS rat model induced by the administration of 30% sucrose in drinking water. We determined in control, MS, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>MS<\/mml:mtext><mml:mo>+<\/mml:mo><mml:mtext>HSL<\/mml:mtext><\/mml:math>rat hearts (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math>per group) cardiac mechanical performance (CMP), coronary vascular resistance (CVR), and activities of manganese and copper\/zinc superoxide dismutases (Mn and Cu\/Zn-SOD), peroxidases, glutathione peroxidase (GPx), catalase (CAT), glutathione s-transferase (GST), glutathione reductase (GR), and glutathione (GSH). We also determined lipoperoxidation (LPO), total antioxidant capacity (TAC), and the nitrate\/nitrite ratio (NO<jats:sub>3<\/jats:sub><jats:sup>-<\/jats:sup>\/NO<jats:sub>2<\/jats:sub><jats:sup>-<\/jats:sup>). The treatment with the HSL infusion restored the CMP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and CVR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>) and increased the Mn- (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), Cu\/Zn-SOD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), peroxidases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>), GST (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) activity, GHS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), TAC (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>), and NO<jats:sub>3<\/jats:sub><jats:sup>-<\/jats:sup>\/NO<jats:sub>2<\/jats:sub><jats:sup>-<\/jats:sup>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and decreased the LPO (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) in the heart of MS rats undergoing ischemia\/reperfusion. The results suggest that the treatment with an infusion from HSL calices protects the cardiac function from damage by ischemia and reperfusion through the antioxidant activities of the substances it possesses. It favors antioxidant enzymatic activities and nonenzymatic antioxidant capacity.<\/jats:p>","DOI":"10.1155\/2019\/1724194","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:32:43Z","timestamp":1553643163000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Myocardial Protection from Ischemia-Reperfusion Damage by the Antioxidant Effect of<i>Hibiscus sabdariffa Linnaeus<\/i>on Metabolic Syndrome Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-2954","authenticated-orcid":true,"given":"Israel","family":"P\u00e9rez-Torres","sequence":"first","affiliation":[{"name":"Department of Pathology, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, M\u00e9xico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-7482","authenticated-orcid":true,"given":"Juan Carlos","family":"Torres-Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, M\u00e9xico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-7590","authenticated-orcid":true,"given":"Ver\u00f3nica","family":"Guarner-Lans","sequence":"additional","affiliation":[{"name":"Department of Physiology, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d, M\u00e9xico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulises","family":"D\u00edaz-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Vasco de Quiroga 15, Secci\u00f3n XVI, Tlalpan, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d, 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