{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:34:12Z","timestamp":1789475652853,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2019,4,18]]},"abstract":"<jats:p>Parry\u2013Romberg syndrome (PRS) is a rare disorder characterized by unilateral facial atrophy. Currently, the pathogenesis of PRS is poorly understood and no definitive treatment is available. This article reports the case of a 51-year-old woman with progressive hemifacial atrophy following herpes zoster infection, who presented with a concomitant chronic history of heat-induced diplopia. Magnetic resonance imaging showed unilateral cerebral white matter, periventricular, and medial longitudinal fasciculus lesions. The patient\u2019s diplopia resolved following treatment with valacyclovir. Infection has been previously considered as potential cause of PRS. However, herpes-induced PRS with ophthalmologic manifestations of Uhthoff\u2019s phenomena has not previously been reported. The present case suggests that PRS may possibly have an autoimmune etiology resembling that of multiple sclerosis.<\/jats:p>","DOI":"10.1155\/2019\/1752456","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T19:33:28Z","timestamp":1555616008000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Parry\u2013Romberg Syndrome with Uhthoff\u2019s Phenomena: A Spectrum of Autoimmune Disease?"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7556-0155","authenticated-orcid":true,"given":"Samuel","family":"Asanad","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine, University of California, Los Angeles, USA"},{"name":"Doheny Eye Institute, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"1","volume":"20","year":"2009","journal-title":"Journal of Neurogenetics"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31818bed6d"},{"key":"3","first-page":"112","volume":"11","year":"2006","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ijporl.2004.12.004","volume":"69","year":"2005","journal-title":"International Journal of Pediatric Otorhinolaryngology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-010-0103-y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.12.969"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510130046011"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/703017"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2011.41.4.183"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.089037"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2011.2205"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.03.009"},{"issue":"47","key":"14","volume":"95","year":"2016","journal-title":"Medicine (United States)"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120227"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.20517\/2347-8659.2015.41"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.5.726"},{"issue":"4","key":"18","first-page":"751","volume":"18","year":"1997","journal-title":"American Journal of Neuroradiology"}],"container-title":["Case Reports in Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2019\/1752456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2019\/1752456.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2019\/1752456.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T19:33:30Z","timestamp":1555616010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crii\/2019\/1752456\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,18]]},"references-count":18,"alternative-id":["1752456","1752456"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1752456","relation":{},"ISSN":["2090-6609","2090-6617"],"issn-type":[{"value":"2090-6609","type":"print"},{"value":"2090-6617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,18]]}}}