{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:30:14Z","timestamp":1740169814192,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,3]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL.<jats:italic> Methods.<\/jats:italic> A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with<jats:italic> K-<\/jats:italic>value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (<jats:italic>K<\/jats:italic>1,<jats:italic> K<\/jats:italic>2, and<jats:italic> K<\/jats:italic>max), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including<jats:italic> K<\/jats:italic>max and TCT, was analyzed.<jats:italic> Results.<\/jats:italic> Linear regression model revealed the KEA,<jats:italic> K<\/jats:italic>max,<jats:italic> K<\/jats:italic>1, and<jats:italic> K<\/jats:italic>2 decreased after CXL in model y = 0.9622 -0.02408 x (P&lt;0.05), y = 0.9982 -0.003469 x(P&lt;0.05), y = 0.9977 + -0.001347 x(P&lt;0.05), y = 0.9992 + -0.001779 x(P&lt;0.05) (y represents KEA,<jats:italic> K<\/jats:italic>max,<jats:italic> K<\/jats:italic>1, or<jats:italic> K<\/jats:italic>2; x represents time (month)). The KEA is significantly decreased in early stage (before month 3) (P&lt;0.05); however, the<jats:italic> K<\/jats:italic>max,<jats:italic> K<\/jats:italic>1, and<jats:italic> K<\/jats:italic>2 have no significant decrease in early stage (P= 0.09, 0.19, 0.32).<jats:italic> Conclusions. <\/jats:italic>The KEA is more sensitive than<jats:italic> K-<\/jats:italic>value in describing the morphological changes of cornea after CXL, especially in early stage after treatment.<\/jats:p>","DOI":"10.1155\/2019\/1762537","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:31:08Z","timestamp":1554319868000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Whether Keratectasia Area Shown in Corneal Topography Is Appropriate for Evaluating the Effect of Corneal Cross-Linking for Keratoconus: A 12-Month Follow-Up Study"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China"},{"name":"Department of Ophthalmology, The Second People\u2019s Hospital of Liaocheng, Linqing 252600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huankai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of 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