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Calibration curve of sirolimus was acquired over a concentration ranging from 2.5 to 100\u2009ng\/mL with r<jats:sup>2<\/jats:sup>= 0.9955. The matrix effects and extraction recoveries of sirolimus ranged from 144% to 152% and from 80% to 96%, respectively. The inter- and intraday relative standard deviations were both &lt;10%. The stability investigation showed that the blood samples were stable for 30-day-storage at <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:math>20\u00b0C, for 8\u2009h storage at room temperature, for 24\u2009h storage in the auto-sampler at 4\u00b0C, and for three freeze-thaw cycle process. The pharmacokinetic results demonstrated that the <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mi>C<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">x<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>,<\/mml:mo><\/mml:math> AUC, and AUMC of sirolimus in rats (7.5\u2009mg\/kg, i.g.) were increased after beincoadministration with Tanreqing Injection at 2.5, 5.0, and 7.5\u2009mL\/kg (i.v.), respectively, or at 5\u2009min, 2\u2009h, and 4\u2009h (5.0\u2009mL\/kg, i.v.) after SRL dosing, respectively. For the first time, the results proved the herb-drug interaction between Tanreqing Injection and sirolimus and accordingly suggested avoiding concurrent reception of those two drugs for patients.<\/jats:p>","DOI":"10.1155\/2019\/1854323","type":"journal-article","created":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T19:30:40Z","timestamp":1552246240000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats"],"prefix":"10.1155","volume":"2019","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, 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