{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:22Z","timestamp":1759336342410,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473442","81971775","31600968","2017060201010166"],"award-info":[{"award-number":["81473442","81971775","31600968","2017060201010166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473442","81971775","31600968","2017060201010166"],"award-info":[{"award-number":["81473442","81971775","31600968","2017060201010166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473442","81971775","31600968","2017060201010166"],"award-info":[{"award-number":["81473442","81971775","31600968","2017060201010166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Wuhan Science and Technology Department","award":["81473442","81971775","31600968","2017060201010166"],"award-info":[{"award-number":["81473442","81971775","31600968","2017060201010166"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,12,26]]},"abstract":"<jats:p>Electroacupuncture (EA) has effective analgesic effects. Our previous study demonstrated that the upregulation of P2X3 receptors in the dorsal root ganglia (DRG) might participate in heroin withdrawal-induced hyperalgesia. The aim of this study is to further explore whether 2\u2009Hz EA reduces heroin relapse associated with its analgesic effect and whether P2X3 receptors in the DRG are involved in this process. 2\u2009Hz EA was adopted to treat the heroin SA rats in the present study. Heroin-seeking and pain sensitivity were evaluated. The expression of P2X3 receptors in the DRG was detected. Our results showed that compared with the control group, the reinstatement, thermal hyperalgesia, and mechanical allodynia of the heroin-addicted group were increased significantly. The expression of P2X3 receptors in the DRG was increased markedly. After being treated using 2\u2009Hz EA, reinstatement was reduced, hyperalgesia was decreased, and the upregulated expression of P2X3 receptors in the DRG had decreased significantly compared to that in the heroin-addicted group. Consequently, our results indicated that 2\u2009Hz EA was an effective method for treating heroin-induced hyperalgesia and helping prevent relapse, and the potential mechanism might be related to the downregulation of P2X3 receptor expression in the DRG.<\/jats:p>","DOI":"10.1155\/2019\/1873859","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T18:30:28Z","timestamp":1577385028000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["2\u2009Hz EA Reduces Heroin Withdrawal-Induced Hyperalgesia and Heroin Relapse by Downregulating P2X3 Receptors in DRG Neurons"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-1202","authenticated-orcid":true,"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"School of Physical Education, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlong","family":"Leng","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokang","family":"Gong","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baomiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Ru","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Tian","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yue","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-4471","authenticated-orcid":true,"given":"Yuxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Physical Education, Jianghan University, Wuhan 430056, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.09.030"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843x.97.2.118"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5010-04.2005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1472-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200107000-00040"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000164"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079567"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5857-09.2010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.10.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.01.078"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1263-x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/35039519"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/wnr.0b013e328336b6c8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/wnr.0000000000001018"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(97)00394-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.05.004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.12.012"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.05.001"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/286404"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/amr.998-999.164"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.03.014"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-018-0312-9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(93)90069-3"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.51"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.21-11-04074.2001"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/s0885-3924(00)00191-3"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2007.02011.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.07.007"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.07.007"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01310.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.12.011"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(03)02798-7"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706346"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/fbp.0000000000000105"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.05.031"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.01.006"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/387505a0"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.07.084"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1998.0719"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-013-1135-6"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/nn1992"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1873859.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1873859.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1873859.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T18:30:31Z","timestamp":1577385031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/1873859\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,26]]},"references-count":43,"alternative-id":["1873859","1873859"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1873859","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2019,12,26]]}}}