{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:01:53Z","timestamp":1774879313529,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Government","award":["NRF- 2016M3C7A1905386"],"award-info":[{"award-number":["NRF- 2016M3C7A1905386"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,7,24]]},"abstract":"<jats:p>The mortality of individuals suffering from depression has been increasing, noticeably of postmenopausal women; consequently, their care and treatment are significant to retain a high quality of life. The aim of this study was to examine the effect of<jats:italic> Camellia sinensis<\/jats:italic> (CS) on repeated stress-induced changes of the depression related function on the tail suspension test (TST), forced swimming test (FST) in ovariectomized female rats. After behavioral test, we evaluated the changes in the neurotransmitter by measuring the level of dopamine in the nucleus accumbens (NaC) and the serum levels of estrogen and oxytocin. We used 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to examine the effects of CS on glucose metabolism in ovariectomized rats. Female rats were randomly segregated into three groups. Nor group was considered as nonoperated and nonstressed group, while the control was the ovariectomized and stressed group (OVX+ST), and CS was the ovariectomized, stressed and CS treated group. The rats were exposed to immobilization stress (IMO) for 14 d (2\u2009h\/d), and CS (300\u2009mg\/kg, i.p.) was treated 30\u2009min before IMO stress. Significant reduction of immobility in the TST and FST was indicated in rats treatment with CS compared to the control group (OVX+ST). The levels of estrogen in the serum of the Nor and CS groups were significantly elevated compared to the OVX+ST group. Also, CS activated brain glucose metabolism in the cortex. The present findings suggested that CS had antidepressant effectiveness in a menopausal depression animal model. These findings suggest evidence that CS plays a crucial role in stressful situation, providing that CS might be a dependable antidepressant medicine to treat menopausal depression.<\/jats:p>","DOI":"10.1155\/2019\/1926352","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:30:40Z","timestamp":1563996640000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Effects of<i> Camellia Sinensis<\/i> Extract on Repeated Restraint Stress-Induced Ovariectomized Female Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-7992","authenticated-orcid":true,"given":"Minsook","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daehyuk","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02435, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Molecular Imaging Research Center, Korea Institute of Radiological & Medical Sciences University of Science & Technology, #215-4 Gongneug-dong, Nowon-ku, Seoul 139-241, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-1212","authenticated-orcid":true,"given":"Kyungsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea"},{"name":"Department of Family Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-9782","authenticated-orcid":true,"given":"Insop","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02435, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s40695-015-0002-y"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_7.16S"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.11.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.16.5.305"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0302"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.07.026"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1021\/jf000877h"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.70108"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/164943"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00287.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803523662"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2009.13.2.85"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200713216"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428203"},{"issue":"2","key":"15","first-page":"327","volume":"229","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652050-00001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000435"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1825"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1926352.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1926352.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1926352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:30:43Z","timestamp":1563996643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/1926352\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":18,"alternative-id":["1926352","1926352"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1926352","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]}}}