{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:30:01Z","timestamp":1740169801799,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Fund of Science and Technology Agency of Sichuan Province","award":["14JC01773-LH72"],"award-info":[{"award-number":["14JC01773-LH72"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,2,21]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Vasculogenic mimicry (VM), as an endothelium-independent cancer microcirculation, has been observed in many malignancies including cervical cancer. Erythropoietin (EPO) and erythropoietin receptor (EPO-R) could produce an angiogenic effect to promote cervical squamous cell carcinoma (CSCC) progression. However, the association between VM formation and EPO\/EPO-R expression in CSCC is poorly explored.<jats:italic> Methods.<\/jats:italic> Seventy-six paraffin-embedded CSCC samples, 25 high-grade squamous intraepithelial lesion (HSIL) samples, 20 low-grade squamous intraepithelial lesion (LSIL) samples, and 20 normal cervix samples were collected. Immunohistochemistry SP method was performed to detect EPO\/EPO-R expression and CD31\/periodic acid-Schiff (PAS) double staining was performed to detect VM formation. The associations of EPO\/EPO-R and VM with clinicopathological parameters of CSCC were analyzed. The associations between VM formation and EPO\/EPO-R expression were also analyzed.<jats:italic> Results.<\/jats:italic> The positive expression rates of EPO and EPO-R were gradually increasing along the progression of normal cervix-LSIL-HSIL-CSCC sequence (<jats:italic>P<\/jats:italic>&lt;0.05). EPO and EPO-R expression were not significantly associated with clinicopathological parameters of CSCC patients (<jats:italic>P<\/jats:italic>&gt;0.05). VM was significantly associated with FIGO stage, lymphovascular space involvement, and lymph node metastasis (<jats:italic>P<\/jats:italic>&lt;0.05). VM was positively associated with EPO expression (<jats:italic>r<\/jats:italic>=0.284,<jats:italic> P<\/jats:italic>&lt;0.05) but was not associated with EPO-R expression (<jats:italic>P<\/jats:italic>&gt;0.05).<jats:italic> Conclusion.<\/jats:italic> These data suggest that increased EPO\/EPO-R expression may play an important role in cervical carcinogenesis. EPO overexpression may promote VM formation in CSCC.<\/jats:p>","DOI":"10.1155\/2019\/1934195","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T18:31:09Z","timestamp":1550773869000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2019","author":[{"given":"Yue-Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qing","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan province, 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