{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:43:55Z","timestamp":1783745035723,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2019,10,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Low vitamin D serum levels have been associated with many autoimmune disorders and several other skin diseases. Vitiligo is an autoimmune disease characterized by destruction of melanocytes by immune mechanisms. Melanocytes express vitamin D receptors, and their function can be affected by vitamin D status. <jats:italic>Objectives<\/jats:italic>. The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo. <jats:italic>Methods<\/jats:italic>. A case-control study was conducted. 100 vitiligo patients and 100 as controls were included in this study. Serum vitamin D level was measured for both vitiligo patients and controls, results were compared, and statistical analysis was done to compare the results. <jats:italic>Results<\/jats:italic>. The median age of vitiligo cases was 23 years (ranges, 2\u201380). 58% of vitiligo patients were females. The median vitamin D level was not significantly different between the two groups (vitiligo\u2009=\u200914.1 (IQR 9.9\u201320.4) vs control\u2009=\u200916.5 (IQR 10.3\u201325.3) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.28<\/mml:mn><\/mml:mrow><\/mml:math>)). Most vitiligo cases and controls were found to have low levels of vitamin D (either insufficient 20\u201330\u2009ng\/mL or low &lt;20\u2009ng\/mL). <jats:italic>Conclusions<\/jats:italic>. There was no significant difference in vitamin D levels in vitiligo patients compared to controls. However, vitamin D levels were generally low in both groups.<\/jats:p>","DOI":"10.1155\/2019\/2048409","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T19:30:19Z","timestamp":1570735819000},"page":"1-4","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-0221","authenticated-orcid":true,"given":"Diala M.","family":"Alshiyab","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-7406","authenticated-orcid":true,"given":"Firas A.","family":"Al-qarqaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen H.","family":"Heis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihan M.","family":"Muhaidat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wlla S.","family":"Eddin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausama A.","family":"Atwan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Royal Gwent Hospital, Newport, 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