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Nevertheless, these tumors share very high incidence and mortality rates worldwide and patients\u2019 poor prognosis. Therefore, the identification of specific biomarkers could increase the development of personalized medicine, in order to improve GI cancer management. In this sense, HMGA family members (HMGA1 and HMGA2) comprise an important group of genes involved in the genesis and progression of malignant tumors. Additionally, it has also been reported that HMGA1 and HMGA2 display an important role in the detection and progression of GI tumors. In this way, HMGA family members could be used as reliable biomarkers able to efficiently track not only the tumor <jats:italic>per se<\/jats:italic> but also the main risk conditions related with their development of GI cancers in the future. 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