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In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role. The first aim of this study was to investigate the<jats:italic>CXCR2<\/jats:italic>gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. The second aim was to find a relation between<jats:italic>CXCR2<\/jats:italic>gene variants and the presence of periodontal bacteria. A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C\/T (rs2230054), +1208T\/C (rs1126579), and +1440A\/G (rs1126580). A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>162<\/mml:mn><\/mml:math>). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of<jats:italic>CXCR2<\/jats:italic>gene variants between patients with CP and healthy controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) were determined. Nevertheless,<jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>was detected more frequently in men positive for the C allele of the<jats:italic>CXCR2<\/jats:italic>+785C\/T polymorphism (61.8% vs. 41.1%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.31<\/mml:mn><\/mml:math>, 95%<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.03<\/mml:mn><\/mml:math>-5.20) and for the T allele of the<jats:italic>CXCR2<\/jats:italic>+1208C\/T variant (61.8% vs. 38.9%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.54<\/mml:mn><\/mml:math>, 95%<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.13<\/mml:mn><\/mml:math>-5.71). In contrast, no statistically significant associations of<jats:italic>CXCR2<\/jats:italic>variants with seven selected periodontal bacteria were found in women. Although none of the investigated SNPs in the<jats:italic>CXCR2<\/jats:italic>gene was associated with CP, the<jats:italic>CXCR2<\/jats:italic>gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.<\/jats:p>","DOI":"10.1155\/2019\/2061868","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:32:03Z","timestamp":1549323123000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Chemokine Receptor 2 (<i>CXCR2<\/i>) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Denisa","family":"Kavrikova","sequence":"first","affiliation":[{"name":"Clinic of Stomatology, Institution Shared with St. Anne\u2019s Faculty Hospital, Faculty of Medicine, Masaryk University, Pekarska 664\/53, 60200 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-3615","authenticated-orcid":true,"given":"Petra","family":"Borilova Linhartova","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology, Institution Shared with St. Anne\u2019s Faculty Hospital, Faculty of Medicine, Masaryk University, Pekarska 664\/53, 60200 Brno, Czech Republic"},{"name":"Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Lucanova","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology, Institution Shared with St. Anne\u2019s Faculty Hospital, Faculty of Medicine, Masaryk University, Pekarska 664\/53, 60200 Brno, Czech 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