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However, chronic BDZ use elicits several adverse reactions. Reportedly, aromatherapy is safer for the management of anxiety. Bergamot essential oil (BEO) extracted from <jats:italic>Citrus bergamia<\/jats:italic> Risso <jats:italic>et<\/jats:italic> Poiteau fruit, like other essential oils, is widely used in aromatherapy to relieve symptoms of stress-induced anxiety. Interestingly, preclinical data indicate that BEO induces anxiolytic-like\/relaxant effects in animal behavioural tasks not superimposable to those of benzodiazepine diazepam. To better elucidate the involvement of GABAergic transmission, the present study examines the effects of pretreatment with flumazenil (FLZ), a benzodiazepine site antagonist, on BEO effects using open-field task (OFT) in rats. The data yielded show that FLZ does not significantly affect behavioural effects of the phytocomplex. These results demonstrate the lack of overlapping between BEO and BDZ behavioural effects, contributing to the characterization of the neurobiological profile of the essential oil for its rational use in aromatherapy.<\/jats:p>","DOI":"10.1155\/2019\/2156873","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T19:31:01Z","timestamp":1565811061000},"page":"1-6","source":"Crossref","is-referenced-by-count":32,"title":["Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-3158","authenticated-orcid":true,"given":"Laura","family":"Rombol\u00e0","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-7058","authenticated-orcid":true,"given":"Damiana","family":"Scuteri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annagrazia","family":"Adornetto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Straface","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Sakurada","sequence":"additional","affiliation":[{"name":"First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, 815-8511 Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Sakurada","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 981-8558 Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 981-8558 Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tiziana","family":"Corasaniti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-6218","authenticated-orcid":true,"given":"Giacinto","family":"Bagetta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tonin","sequence":"additional","affiliation":[{"name":"Regional Center for Serious Brain Injuries, S. 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