{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:58:52Z","timestamp":1765231132348,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,8,25]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Blackwater fever (BWF) is a rare but serious complication of malaria that is a consequence of antimalarial treatment. Its prevalence seems to have increased. Its diagnosis is based on clinical symptoms and urine color. We report on 4 BWF cases admitted to the infectious diseases department of Zinder National Hospital. <jats:italic>Results<\/jats:italic>. Four patients were hospitalized in September 2017 for a hepatorenal syndrome of jaundice, port wine-colored urine, renal failure, and hepatic cytolysis following antimalarial treatment with quinine salts. Quinine treatment was stopped and treatment was continued with injectable artemether. Three patients underwent extra-renal purification. Their evolution was favorable. One patient died less than 24\u2009hours after admission. <jats:italic>Conclusion<\/jats:italic>. A rare and severe complication, blackwater fever must be considered for patients under antimalarial treatment who present with jaundice, abdominal pain, and acute renal insufficiency with port wine-colored urine. Rapid diagnosis and management in an intensive care unit are crucial for improving the prognosis.<\/jats:p>","DOI":"10.1155\/2019\/2346087","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T19:30:38Z","timestamp":1566761438000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-5293","authenticated-orcid":true,"given":"Doutchi","family":"Mahamadou","sequence":"first","affiliation":[{"name":"National Hospital of Zinder, Zinder, Niger"},{"name":"Faculty of Health Sciences, University of Zinder, Zinder, Niger"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diongol\u00e9 M.","family":"Hassane","sequence":"additional","affiliation":[{"name":"National Hospital of Zinder, Zinder, Niger"},{"name":"Faculty of Health 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