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Understanding the difference in the expression and localization of tissue-specific H<jats:sub>2<\/jats:sub>S-producing enzymes in healthy and cancer tissues allows us to develop tools for cancer diagnosis and treatment. Urological malignancies are some of the most common cancers in both men and women, and their early detection is vital since advanced cancers are recurrent, metastatic, and often resistant to treatment. This review summarizes the roles of H<jats:sub>2<\/jats:sub>S in cancer and looks at current studies investigating H<jats:sub>2<\/jats:sub>S activity and expression of H<jats:sub>2<\/jats:sub>S-producing enzymes in urinary cancers. We specifically focused on urothelial carcinoma, renal cell carcinoma, and prostate cancer, as they form the majority of newly diagnosed urinary cancers. Recent studies show that besides the physiological activity of H<jats:sub>2<\/jats:sub>S in cancer cells, there are patterns between the development and prognosis of urinary cancers and the expression of H<jats:sub>2<\/jats:sub>S-producing enzymes and indirectly the H<jats:sub>2<\/jats:sub>S levels. Though controversial and not completely understood, studying the expression of H<jats:sub>2<\/jats:sub>S-producing enzymes in cancer tissue may represent an avenue for novel diagnostic and therapeutic strategies for addressing urological malignancies.<\/jats:p>","DOI":"10.1155\/2019\/2360945","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T18:31:14Z","timestamp":1572805874000},"page":"1-10","source":"Crossref","is-referenced-by-count":28,"title":["Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-7302","authenticated-orcid":true,"given":"Masoud","family":"Akbari","sequence":"first","affiliation":[{"name":"Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, Dental Sciences Building, Rm 3014, London, Ontario, Canada N6A 5C1"},{"name":"Matthew Mailing Center for 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