{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:29:09Z","timestamp":1769934549408,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773320"],"award-info":[{"award-number":["81773320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,2,17]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Abnormal apoptosis of keratinocytes is one of the pathological changes of psoriasis. Caspases (CASPs) are the central engines of apoptosis. Studies to date have shown that some SNPs alter the expression of related genes and lead to changes in disease risk. However, no studies have investigated the associations between gene polymorphisms and the risk of psoriasis in Han population in northeast China. Therefore, we conducted a case-control study to explore this question in Han population of northeastern China.<jats:italic> Methods<\/jats:italic>. 540 patients with PsV and 612 healthy age- and sex-matched controls were enrolled in this study. We determined the genotypes of 17 single nucleotide polymorphisms (SNPs) from 11 genes of caspase family by the improved multiplex ligation detection reaction (iMLDR) method. A model-based single SNP frequentist test and haplotype association studies were performed to evaluate the association between SNPs and PsV.<jats:italic> Results<\/jats:italic>. In the single SNP tests, rs6704688 in<jats:italic> CASP8<\/jats:italic> was significantly associated with psoriasis vulgaris (PsV) in Han population of northeastern China (P = 0.0169, P\u2019 = 0.0179 under the additive model;<jats:italic> P<\/jats:italic> = 0.0126,<jats:italic> P\u2019<\/jats:italic> = 0.0149 under the heterozygous model). In haplotype analyses, the<jats:italic> CASP7<\/jats:italic> haplotype GC was found to be associated with PsV risk (case group versus control group, 47.2% versus 54.4%, respectively,<jats:italic> p<\/jats:italic> = 0.0149).<jats:italic> Conclusions<\/jats:italic>. Our study presented that the gene polymorphisms of<jats:italic> CASP7<\/jats:italic> and<jats:italic> CASP8<\/jats:italic> were significantly associated with PsV in Han population of northeastern China, which implied the functional relationship between PsV and caspase genes.<jats:italic> CASP8<\/jats:italic> and<jats:italic> CASP7<\/jats:italic> SNPs could be new potential biomarkers for risk stratification and prevention of PsV.<\/jats:p>","DOI":"10.1155\/2019\/2417612","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T18:30:47Z","timestamp":1550428247000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China"],"prefix":"10.1155","volume":"2019","author":[{"given":"Xinyu","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Peking University First Hospital, Beijing, 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-6651","authenticated-orcid":true,"given":"Pei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, 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