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However, the mechanism underlying this association remains poorly understood. In the present study, a gilt obesity model was developed by exposure to different energy diets and used to investigate the role of NADPH oxidase 2 (Nox2) in the placenta. Specifically, 99 gilts (Guangdong Small-ear Spotted pig) at day 60 of gestation were randomly assigned to one of the following three treatments: low-energy group (L,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mtext>DE<\/mml:mtext>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>11.50<\/mml:mn>\n                      <mml:mtext>\u2009<\/mml:mtext>\n                      <mml:mtext>MJ<\/mml:mtext>\n                      <mml:mo>\/<\/mml:mo>\n                      <mml:mtext>kg<\/mml:mtext>\n                    <\/mml:math>\n                    ), medium-energy group (M,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mtext>DE<\/mml:mtext>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>12.41<\/mml:mn>\n                      <mml:mtext>\u2009<\/mml:mtext>\n                      <mml:mtext>MJ<\/mml:mtext>\n                      <mml:mo>\/<\/mml:mo>\n                      <mml:mtext>kg<\/mml:mtext>\n                    <\/mml:math>\n                    ), and high-energy group (H,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mtext>DE<\/mml:mtext>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>13.42<\/mml:mn>\n                      <mml:mtext>\u2009<\/mml:mtext>\n                      <mml:mtext>MJ<\/mml:mtext>\n                      <mml:mo>\/<\/mml:mo>\n                      <mml:mtext>kg<\/mml:mtext>\n                    <\/mml:math>\n                    ), with 11 replicate pens per treatment and 3 gilts per pen. At the start of the study, maternal body weight and backfat thickness were not significantly different in the three treatments. After the study, data indicated that the H group had higher body weight and backfat thickness gain for gilts during gestation and lower piglet birth weight compared with the other two groups. Additionally, the H group showed glucolipid metabolic disorders and increased triglyceride and nonesterified fatty acid contents in the placenta of gilts. Compared with the L group, the H group exhibited lower mitochondrial biogenesis and increased oxidative damage in the placenta. Importantly, increased mRNA expression and protein abundance of Nox2 were observed for the first time in H group placentae. Furthermore, compared with the L group, the H group showed a decrease in the density of placental vessels and the protein levels of vascular endothelial cadherin (VE-cadherin), vascular endothelial growth factor A (VEGF-A), and phosphorylation of vascular endothelial growth factor receptor 2 (p-VEGFR2) as well as the immunostaining intensity of platelet endothelial cell adhesion molecule-1 (CD31). Our findings suggest that maternal high-energy diet-induced obesity increases placental oxidative stress and decreases placental angiogenesis possibly through the upregulation of Nox2.\n                  <\/jats:p>","DOI":"10.1155\/2019\/2481592","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:30:24Z","timestamp":1569958224000},"page":"1-13","source":"Crossref","is-referenced-by-count":51,"title":["Maternal Diet-Induced Obesity Compromises Oxidative Stress Status and Angiogenesis in the Porcine Placenta by Upregulating Nox2 Expression"],"prefix":"10.1155","volume":"2019","author":[{"given":"Chengjun","family":"Hu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Yihao Foodstuffs Co. 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