{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:57:07Z","timestamp":1775854627367,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Slaski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["KNW-2-K36\/D\/6\/N"],"award-info":[{"award-number":["KNW-2-K36\/D\/6\/N"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007771","name":"Slaski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["KNW-2-026\/D\/5\/N"],"award-info":[{"award-number":["KNW-2-026\/D\/5\/N"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007771","name":"Slaski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["KNW-2-K36\/D\/6\/N"],"award-info":[{"award-number":["KNW-2-K36\/D\/6\/N"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007771","name":"Slaski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["KNW-2-026\/D\/5\/N"],"award-info":[{"award-number":["KNW-2-026\/D\/5\/N"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Insufficient vitamin D and calcium intake associated with the restricted intake of milk and dairy products can lead to poor health outcomes like malnutrition and abnormal bone mineralization. The aim of the study was to estimate the prevalence of primary and secondary lactose intolerance in children with IBD. <jats:italic>Methods<\/jats:italic>. The study included 107 patients (mean age <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>14.07<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.58<\/mml:mn><\/mml:math> years; 46.7% boys) which includes 43 patients with Crohn\u2019s disease (CD), 31 with ulcerative colitis (UC), and 33 children with functional abdominal pain (AP-FGID). We analysed the result of the hydrogen breath test with lactose loading, two single nucleotide polymorphisms of the <jats:italic>LCT<\/jats:italic> gene (LCT-13910CC and LCT-22018GG). The results were analysed with MedCalc Statistical Software. <jats:italic>Results<\/jats:italic>. Adult-type hypolactasia (ATH) was found in 31% of patients with IBD and 42.4% of AP-FGID (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.2<\/mml:mn><\/mml:math>). Lactose malabsorption (LM) was found in 27.9% of patients with CD, in 22.6% with UC, and in 24.2% with AP-FGID (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.8<\/mml:mn><\/mml:math>). Lactose intolerance (LI) was diagnosed in a similar percentage of patients in each group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.9<\/mml:mn><\/mml:math>). Secondary LI in IBD patients does not depend on the location, duration, and activity of the disease and the number of relapses (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The median time of lactose-free diet in CD was 10 months and in CU 24 months. <jats:italic>Conclusions<\/jats:italic>. The incidence of LI, LM, and ATH does not differ among children with IBD from the population.<\/jats:p>","DOI":"10.1155\/2019\/2507242","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T07:49:37Z","timestamp":1575272977000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-7667","authenticated-orcid":true,"given":"Martyna","family":"Jasielska","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-7461","authenticated-orcid":true,"given":"Urszula","family":"Grzybowska-Chlebowczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03557.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1721"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i2.187"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/03014468400007211"},{"issue":"4","key":"7","first-page":"585","volume":"57","year":"2010","journal-title":"Acta Biochimica Polonica"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000798"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-4-7"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-016-0183-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199105000-00005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.029"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/26337"},{"issue":"5","key":"18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/00365520310000555a","volume":"38","year":"2003","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-339"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.02.048"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-4-6"},{"issue":"2","key":"22","first-page":"207","volume":"61","year":"2015","journal-title":"Pomeranian journal of life sciences"},{"key":"23","first-page":"114","volume":"19","year":"2012","journal-title":"Gastroenterologia Polska"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.3994"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200209000-00019"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200201000-00009"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-12-201006150-00241"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3109\/08910609309141564"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.2.232"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14305"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/2507242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/2507242.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/2507242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T07:49:40Z","timestamp":1575272980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2019\/2507242\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"references-count":29,"alternative-id":["2507242","2507242"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2507242","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,1]]}}}