{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:22:27Z","timestamp":1770153747586,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T00:00:00Z","timestamp":1549152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Plan","award":["2017YFC17001"],"award-info":[{"award-number":["2017YFC17001"]}]},{"name":"National Key Research and Development Plan","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Foundation of Beijing University of Chinese Medicine Basic Scientific Research Business Expenses","award":["2017YFC17001"],"award-info":[{"award-number":["2017YFC17001"]}]},{"name":"Foundation of Beijing University of Chinese Medicine Basic Scientific Research Business Expenses","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Beijing Common special construction projects","award":["2017YFC17001"],"award-info":[{"award-number":["2017YFC17001"]}]},{"name":"Beijing Common special construction projects","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,2,3]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This study investigated the distribution of characteristics of traditional Chinese medicine syndromes and their association with symptoms in 1027 patients with chronic heart failure (CHF).<jats:italic>Methods<\/jats:italic>. An observational study was performed by researchers, collecting data from 1036 patients with CHF from 24 Chinese medicine hospitals from May 2009 to December 2014. Due to incomplete information from nine patients, 1027 patients with CHF were analysed. The distribution of syndromes in CHF and association between high-frequency syndromes and symptoms were investigated.<jats:italic>Results<\/jats:italic>. The primary syndromes were qi deficiency, blood stasis, fluid retention, yin deficiency, phlegm turbidity, and yang deficiency. The primary sites of disease were the heart, kidney, lung, and spleen. In patients with CHF of differing cardiac function, there was no significant difference in the frequency of yin deficiency (P&gt;0.05). The distribution of yang deficiency was significantly different between New York Heat Association (NYHA) classes II, III, and IV and between classes I+II and III+IV (P&lt;0.05). The frequency of phlegm turbidity was significantly different between NYHA classes II and III, between classes III and IV, and between classes I+II and III+IV (P&lt;0.05). The frequency of fluid retention was significantly different between NYHA classes I and IV, between classes II, III, and IV, and between classes I+II and III+IV (P&lt;0.05). Regarding associations between syndromes and symptoms, qi deficiency was diagnosed in 87.43% of patients with insomnia and spiritlessness; blood stasis in 84.85% of patients with spontaneous sweating + cyanosis of the lips; fluid retention in 75% of patients with a hard pulse and oedema; and yin deficiency in 72.92% of patients with feverish sensation in the chest, palms, and soles and spontaneous sweating.<jats:italic>Conclusions<\/jats:italic>. The frequency of yang deficiency and fluid retention was higher and that of phlegm turbidity was lower in classes III and IV than in classes I and II.<\/jats:p>","DOI":"10.1155\/2019\/2543413","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T23:32:29Z","timestamp":1549236749000},"page":"1-12","source":"Crossref","is-referenced-by-count":12,"title":["Study on the Differences between Traditional Chinese Medicine Syndromes in NYHA I\u2013IV Classification of Chronic Heart Failure"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jun","family":"Shi","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"},{"name":"Basic Medical School of Inner Mongolia Medical University, Hohhot 010010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangtao","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-777X","authenticated-orcid":true,"given":"Huihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-3331","authenticated-orcid":true,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(09)60059-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx460"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161924"},{"issue":"2","key":"5","first-page":"98","volume":"42","year":"2014","journal-title":"Chinese Journal of Cardiology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.035"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/242589"},{"issue":"52","key":"8","doi-asserted-by":"crossref","first-page":"90465","DOI":"10.18632\/oncotarget.20063","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6949348"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5779"},{"key":"11","year":"2016"},{"issue":"12","key":"12","first-page":"1076","volume":"35","year":"2007","journal-title":"Chinese Journal of Cardiology"},{"issue":"10","key":"13","first-page":"598","volume":"1986","year":"1986","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"3","key":"14","first-page":"129","volume":"7","year":"1987","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"15","year":"1997"},{"key":"16","year":"2015"},{"issue":"12","key":"17","first-page":"100","volume":"33","year":"2017","journal-title":"Fujian Computer"},{"key":"18","year":"2017"},{"issue":"6","key":"19","first-page":"2040","volume":"29","year":"2014","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"20","first-page":"17","volume":"11","year":"2005","journal-title":"Chinese Journal of Basic Medicine"},{"key":"21","year":"2015"},{"issue":"20","key":"22","first-page":"161","volume":"12","year":"2014","journal-title":"Chinese Medicine Modern Distance Education of China"},{"issue":"5","key":"23","first-page":"419","volume":"24","year":"2007","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"issue":"2","key":"25","first-page":"3","volume":"36","year":"2016","journal-title":"Journal of Hunan University of Traditional Chinese Medicine"},{"issue":"7","key":"26","first-page":"391","volume":"18","year":"1998","journal-title":"Chinese Journal of Integrative Medicine"},{"issue":"10","key":"27","first-page":"585","volume":"8","year":"1988","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"28","year":"2009"},{"issue":"3","key":"29","first-page":"24","volume":"1989","year":"1989","journal-title":"Traditional Chinese Medicine (TCM) in Xinjiang"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1306-7"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/2543413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/2543413.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/2543413.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T05:43:17Z","timestamp":1606369397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/2543413\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,3]]},"references-count":29,"alternative-id":["2543413","2543413"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2543413","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,3]]}}}