{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:43:54Z","timestamp":1773445434763,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007742","name":"BioClinica","doi-asserted-by":"publisher","award":["9\/2743\/9.03.2016"],"award-info":[{"award-number":["9\/2743\/9.03.2016"]}],"id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,7,17]]},"abstract":"<jats:p>Arterial stiffness and arterial age provide valuable prognostic cardiovascular information. The present study aimed at assessing the levels of vitamin D, high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein cholesterol (LDL), and oxidized LDL (oxLDL) in a group of middle-aged hypertensive patients and their relationship with pulse wave velocity (PWV), central blood pressure, and early arterial aging (EAA), respectively. A total of 56 patients, aged <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>48<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>6<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>years<\/mml:mtext><\/mml:math>, 57% males, with hypertension and high normal blood pressure (HNBP), were investigated using a Mobile-O-Graph, to assess central and peripheral blood pressure, PWV, and arterial age. Additionally, hsCRP, LDL, oxLDL, and 25-hydroxy vitamin D3 were assessed. PWV, 25-hydroxy vitamin D3, hsCRP, oxLDL, and LDL levels were <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>7.26<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.69<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>m<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>s<\/mml:mtext><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>25.99<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>11.17<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>microg<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>l<\/mml:mtext><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>0.48<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.44<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>mg<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>dl<\/mml:mtext><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>261.37<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>421<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>ng<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>ml<\/mml:mtext><\/mml:math>, and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>145.73<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>39.53<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>mg<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>dl<\/mml:mtext><\/mml:math>, respectively. Significant correlations were obtained between oxLDL and pulse pressure amplification (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext>rS<\/mml:mtext><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>0.347<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><\/mml:math>) and between hsCRP and LDL levels with PWV and EAA, respectively. ROC curve analysis revealed that hsCRP is a sensitive and specific predictor of EAA and increased PWV values. Concluding, vitamin D deficiency and increased hsCRP and LDL values are very common, and high oxidized LDL is related to pulse pressure amplification in patients with elevated blood pressure. Vitamin D level and high-sensitivity C-reactive protein and LDL provide valuable information in middle-aged hypertensive and HNBP patients related to arterial stiffness and early arterial aging, but only hsCRP is a sensitive predictor of EAA and PWV.<\/jats:p>","DOI":"10.1155\/2019\/2568069","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T19:30:35Z","timestamp":1563391835000},"page":"1-9","source":"Crossref","is-referenced-by-count":30,"title":["Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-7698","authenticated-orcid":true,"given":"Ioana","family":"Mozos","sequence":"first","affiliation":[{"name":"Department of Functional Sciences, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300173 Timisoara, Romania"},{"name":"Center for Translational 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