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PLEKHA7 and COL11A1 were genotyped for single-nucleotide polymorphisms (SNPs) to investigate the possible association of these two genes with primary angle-closure glaucoma (PACG) and disease severity. <jats:italic>Method<\/jats:italic>. A total of 51 PACG cases and 51 normal controls were recruited. Twelve SNPs in the PLEKHA7 (rs216489, rs1027617, rs366590, rs11024060, rs6486330, rs11024097, and rs11024102) and COL11A1 (rs1676484, rs3753841, rs12138977, rs2126642, and rs2622848) genes were genotyped by direct Sanger sequencing. Distributions of allele frequencies and genotype frequencies in cases and controls, as well as in mild, moderate, and severe subgroups, were compared based on mean defect (MD \u2264 6.00\u2009dB, 6\u2009dB &lt; MD \u2264 12\u2009dB, and MD &gt; 12\u2009dB were considered mild, moderate, and severe, respectively). Independent Student\u2019s <jats:italic>t<\/jats:italic>-tests and chi-square tests were used to compare characteristics of PACG cases and controls. Chi-square tests were used to compare the distribution of allele frequencies in cases and controls and in MD-based subgroups with various degrees of glaucoma severity. Binary logistic regression was used to compare the distribution of genotype frequencies and calculate odds ratios (OR) with confidence intervals (CI). <jats:italic>Result<\/jats:italic>. Three of the 12 SNPs in COL11A1, rs1676486 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.026<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.089, 95% CI = 1.092\u20133.996), rs3753841 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.036<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 1.886, 95% CI = 1.038\u20133.426), and rs12138977 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.133, 95% CI = 1.104\u20134.123) were found to have a significant association with PACG. Furthermore, in the subgroup analysis, rs1676486 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.416, 95% CI = 1.284\u20134.544; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.119, 95% CI = 1.204\u20133.729), rs12138977 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.158, 95% CI = 1.287\u20133.618; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 1.962, 95% CI = 1.239\u20133.106), and rs3753841 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:mrow><\/mml:math>, OR = 2.550, 95% CI = 1.344\u20134.839) showed statistically significant differences between moderate\/severe groups and controls. <jats:italic>Conclusion<\/jats:italic>. Our data suggested that COL11A1 rs1676484, rs3753841, and rs12138977 polymorphisms may be of value for further study as potential gene-dependent risk factors for developing PACG. Moreover, COL11A1 rs1676484 and rs12138977 polymorphisms might be associated with PACG disease severity.<\/jats:p>","DOI":"10.1155\/2019\/2604386","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T18:30:46Z","timestamp":1548613846000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["COL11A1 Polymorphisms Are Associated with Primary Angle-Closure Glaucoma Severity"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-5976","authenticated-orcid":true,"given":"Yani","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-740X","authenticated-orcid":true,"given":"Shengjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3131-9287","authenticated-orcid":true,"given":"Yanting","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, 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