{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:34:23Z","timestamp":1747190063625,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PROFOCIE","award":["2016-18MSU0019M-04","2014-18MSU0019M-04-01"],"award-info":[{"award-number":["2016-18MSU0019M-04","2014-18MSU0019M-04-01"]}]},{"name":"PROFOCIE","award":["2016-18MSU0019M-04","2014-18MSU0019M-04-01"],"award-info":[{"award-number":["2016-18MSU0019M-04","2014-18MSU0019M-04-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,10,9]]},"abstract":"<jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory disease whose association with SNPs has led to the identification of biomarkers in different populations. To determine the association of the -857C\/T SNP of the <jats:italic>TNFA<\/jats:italic> gene with RA and clinical parameters, 233 RA patients and 237 healthy controls were included in this study. The -857C\/T polymorphism was determined using the TaqMan\u00ae system and clinical features were also determined. We found that the -857C\/T SNP was in Hardy-Weinberg equilibrium. Our results showed no association of the -857C\/T SNP with RA; however, RA patients carrying the TT genotype showed lower anti-CCP levels than other groups. Therefore, the TT genotype could be a risk factor for developing anti-CCP-negative RA. Our results suggest that the T allele of the <jats:italic>TNFA<\/jats:italic> -857C\/T SNP exerts an influence on anti-CCP levels and could be a candidate marker for anti-CCP-negative RA.<\/jats:p>","DOI":"10.1155\/2019\/2637607","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:32:11Z","timestamp":1570649531000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["The TNFA -857C\/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population"],"prefix":"10.1155","volume":"2019","author":[{"given":"Juan Manuel","family":"Agraz-Cibri\u00e1n","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Nohem\u00ed","family":"Espinoza-De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. de Jes\u00fas","family":"Dur\u00e1n-Avelar","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Vibanco-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Ortiz-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Reumatolog\u00eda, Servicio de Medicina Interna, Instituto Mexicano del Seguro Social HGZ No. 1, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"V\u00e1zquez-Reyes","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Guti\u00e9rrez-Franco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Fabiola","family":"Ay\u00f3n-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-9947","authenticated-orcid":true,"given":"Jos\u00e9 Francisco","family":"Zambrano-Zaragoza","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas, Universidad Aut\u00f3noma de Nayarit, Tepic, Nayarit, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/j.biopha.2017.05.055"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/j.reuma.2012.09.001"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.jaut.2012.05.021"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.autrev.2014.08.012"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1016\/j.semarthrit.2017.04.009"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1002\/art.23549"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.cyto.2012.11.020"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1016\/S1471-4892(03)00049-3"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1002\/art.1780310816"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1093\/rheumatology\/keh550"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.3748\/wjg.v18.i11.1235"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1136\/ard.2010.138461"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1002\/art.1780380107"},{"issue":"2","key":"14","first-page":"117","volume":"11","year":"1993","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"20","key":"15","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","year":"2013","journal-title":"Journal of the American Medical Association"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1007\/s10067-016-3320-z"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1111\/1756-185X.12857"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1016\/j.cyto.2012.09.007"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1371\/journal.pone.0183726"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1016\/j.jbspin.2014.06.001"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1002\/jcla.21638"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.3899\/jrheum.130884"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1136\/ard.2007.084715"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2637607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2637607.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2637607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:32:17Z","timestamp":1570649537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2019\/2637607\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":23,"alternative-id":["2637607","2637607"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2637607","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2019,10,9]]}}}