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Therefore, animal models that share immunologic and clinical features with human RA, such as pristane-induced arthritis (PIA), are valuable tools for assessing the primordial events related to arthritis susceptibility. PIA-resistant HIII and susceptible LIII mice were injected i.p. with pristane, and peritoneal lavage fluid was harvested in the early (7 days) and late (35 days) preclinical phases of PIA. Chemokine and cytokine levels were measured in lavage supernatant with ELISA, peritoneal inflammatory leukocytes were immunophenotyped by flow cytometry, and gene expression was determined by qRT-PCR. Leukocyte recruitment was quantitatively and qualitatively divergent in the peritoneum of HIII and LIII mice, with an early increase of CC chemokines (CCL2\/CCL3\/CCL5\/CCL12\/CCL22) in the susceptible LIII strain. Also, cytokines such as IL-12p40, IL-23, and IL-18 were elevated in LIII mice while IL-6 was increased in HIII animals. The results show that an early peritoneal CC chemokine response is an important feature of arthritis susceptibility and defines potential biomarkers in this model.<\/jats:p>","DOI":"10.1155\/2019\/2641098","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T23:33:03Z","timestamp":1551223983000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Early Peritoneal CC Chemokine Production Correlates with Divergent Inflammatory Phenotypes and Susceptibility to Experimental Arthritis in Mice"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-0520","authenticated-orcid":true,"given":"Cristiano","family":"Rossato","sequence":"first","affiliation":[{"name":"Immunogenetics Laboratory, Butantan Institute, Avenida Vital Brasil, 1500, S\u00e3o Paulo 05503-900, Brazil"},{"name":"Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-900, 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