{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:36:22Z","timestamp":1784126182934,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["BL2014010"],"award-info":[{"award-number":["BL2014010"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,12,25]]},"abstract":"<jats:p><jats:italic>Aim. <\/jats:italic>To compare the effects of once-weekly Dulaglutide with once-daily glargine in poorly oral-antidiabetic controlled patients with type 2 diabetes mellitus (T2DM).<jats:italic> Method. <\/jats:italic>A total of 25 patients with T2DM admitted into Department of Endocrinology from December 2012 to August 2013 were randomly assigned into two groups: Dulaglutide group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>16<\/mml:mn><\/mml:mrow><\/mml:math>) and glargine group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:mrow><\/mml:math>). All patients received either Dulaglutide or glargine treatments for 52\u2009weeks. Continuous glucose monitoring systems (CGMS) were applied to them for two 72\u2009h periods at before and after the treatment each. Patient general clinical data were collected and analyzed.<jats:italic> Result. <\/jats:italic>Fast blood glucose<jats:bold> (<\/jats:bold>FBG) of the glargine group declined more significantly than the Dulaglutide group after treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). The mean blood glucose (MBG), standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursion (MAGE) within a day, the largest amplitude of glycemic excursion (LAGE), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>M<\/mml:mi><\/mml:math>-value, absolute means of daily difference (MODD) of glycemic excursion, the percentage of time (\u22642.8\u2009mmol\/L, \u22643.9\u2009mmol\/L, \u226510.0\u2009mmol\/L, \u226513.9\u2009mmol\/L, 3.9\u20137.8\u2009mmol\/L, and 9\u201310.0\u2009mmol\/L), maximum glycemic value, and minimum glycemic value were similar between the two groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). The incidence of hypoglycemia was also similar between the two groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Though serum levels of TNF-<jats:italic>\u03b1<\/jats:italic>, IL-6, and 8-PGF2<jats:italic>\u03b1<\/jats:italic> all decreased, significant reduction was found in TNF-<jats:italic>\u03b1<\/jats:italic> and 8-PGF2<jats:italic>\u03b1<\/jats:italic>. TNF-<jats:italic>\u03b1<\/jats:italic> was only significantly reduced in the Dulaglutide group, while 8-PGF2<jats:italic>\u03b1<\/jats:italic> was seen in both groups.<jats:italic> Conclusion. <\/jats:italic>For T2DM patients with poorly controlled oral antidiabetic drugs, once-weekly Dulaglutide not only has the same effect on glucose fluctuation as once-daily glargine but also significantly reduced TNF-<jats:italic>\u03b1<\/jats:italic> and 8-PGF2<jats:italic>\u03b1<\/jats:italic> after a 52\u2009week treatment protocol. This trial is registered with ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01648582\">NCT01648582<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2019\/2682657","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T18:30:19Z","timestamp":1577298619000},"page":"1-8","source":"Crossref","is-referenced-by-count":21,"title":["The Effects of Once-Weekly Dulaglutide and Insulin Glargine on Glucose Fluctuation in Poorly Oral-Antidiabetic Controlled Patients with Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-1196","authenticated-orcid":true,"given":"Hui-qin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-7384","authenticated-orcid":true,"given":"Xiao-cen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-6224","authenticated-orcid":true,"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"National Heart Research Institute Singapore, National Heart Centre Singapore, 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