{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:34:28Z","timestamp":1747190068972,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,10,9]]},"abstract":"<jats:p>We present a case of a male Italian patient of 66 years with a history of kidney transplantation in treatment with cyclosporine and methylprednisolone. He visited an ENT clinic and was diagnosed as chronic left purulent otitis media. He began at-home antibiotic therapy with poor benefit. On 09\/13\/18, he was admitted to the hospital \u201cS. Maria \u201dof Terni for persistence of left ear pain and complete hearing loss. Magnetic resonance imaging (MRI) of the brain showed \u201c<jats:italic>in correspondence of the petrous rock and the mastoid\u2026presence of flogistic tissue<\/jats:italic>.\u201d Auricular swabs and later surgical drainage of the purulent material were performed and both were positive for extensively drug-resistant (XDR) <jats:italic>Pseudomonas aeruginosa<\/jats:italic> sensitive only to colistin in absence of synergism with rifampin. The patient underwent antibiotic therapy with ceftolozane-tazobactam, a new generation cephalosporin with anti-Pseudomonas activity and a <jats:italic>\u03b2-<\/jats:italic>lactamase inhibitor, that currently is indicated for the treatment of complicated urinary tract infections and complicated intra-abdominal infections, with complete healing. In literature, it is described a series of 12 patients with severe MDR (multidrug-resistant) <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infections (6 pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical and\/or suboptimal treatment. This study included a case of a male patient of 45 years, affected by Burkitt lymphoma and severe neutropenia, who presented with otitis and mastoiditis, and isolation of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> in surgical drainage of the purulent material of the ear (blood cultures were negative). He underwent antibiotic therapy with ceftolozane\u2013tazobactam at a dosage of 3\u2009g\/8\u2009h for 21.3 days. The patient was healed, but a late recurrence was described because of isolation of ceftolozane-tazobactam-resistant <jats:italic>Pseudomonas<\/jats:italic> after therapy. The possibility of acquiring resistance to ceftolozane-tazobactam should be considered in patients with previous exposure to beta-lactams and with poor response to these antibiotics.<\/jats:p>","DOI":"10.1155\/2019\/2683701","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:32:14Z","timestamp":1570649534000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Use of Ceftolozane-Tazobactam in Patient with Severe Medium Chronic Purulent Otitis by XDR <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-3977","authenticated-orcid":true,"given":"L. M.","family":"Saraca","sequence":"first","affiliation":[{"name":"Clinica di Malattie Infettive, Universit\u00e0 degli Studi di Perugia, A. O. \u201cS. Maria\u201d, Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Di Giuli","sequence":"additional","affiliation":[{"name":"Clinica di Malattie Infettive, A. O. \u201cS. Maria\u201d, Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sicari","sequence":"additional","affiliation":[{"name":"Clinica di Malattie Infettive, Universit\u00e0 degli Studi di Perugia, A. O. \u201cS. Maria\u201d, Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Priante","sequence":"additional","affiliation":[{"name":"Clinica di Malattie Infettive, Universit\u00e0 degli Studi di Perugia, A. O. \u201cS. Maria\u201d, Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lavagna","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Radiologia, A. O. \u201cS. Maria\u201d, Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-8278","authenticated-orcid":true,"given":"D.","family":"Francisci","sequence":"additional","affiliation":[{"name":"Clinica di Malattie Infettive, Universit\u00e0 degli Studi di Perugia, A. O. \u201cS. 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