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However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion\/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT. In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT. Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNF<jats:italic>\u03b1<\/jats:italic>, and MCP1 were determined by immunoassays. Platelet 5HT levels and NEFAs were measured before and after OGTT. The free leptin index was calculated from leptin and sOb-R measurements. Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated. Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.39<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>, corrected<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:math>). Platelet 5HT levels were reduced in response to OGTT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>779<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>237<\/mml:mn><\/mml:math>vs<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>.731<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>217<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>ng<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mn>9<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>platelets,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>). In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation.<\/jats:p>","DOI":"10.1155\/2019\/2714049","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T23:33:07Z","timestamp":1556839987000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-414X","authenticated-orcid":true,"given":"Luis Rodrigo","family":"Cataldo","sequence":"first","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Lund University Diabetes Centre, Clinical Research Center, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Suazo","sequence":"additional","affiliation":[{"name":"Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Olmos","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-2430","authenticated-orcid":true,"given":"Carolina","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-8561","authenticated-orcid":true,"given":"Jos\u00e9 E.","family":"Galgani","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Department of Health Sciences, Nutrition & Dietetics, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Fex","sequence":"additional","affiliation":[{"name":"Lund University Diabetes Centre, Clinical Research Center, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-6941","authenticated-orcid":true,"given":"J. 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