{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:17:14Z","timestamp":1775481434126,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity.<jats:italic>Methods<\/jats:italic>. Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization &lt;0.5 disc diameter\/week were studied in each of them.<jats:italic>Results<\/jats:italic>. The statistically significant variables related to retinal vascular development &lt;0.5 DD\/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4\u20136 weeks (p=0.031).<jats:italic>Conclusion<\/jats:italic>. In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization.<\/jats:p>","DOI":"10.1155\/2019\/2721578","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T23:31:11Z","timestamp":1556148671000},"page":"1-5","source":"Crossref","is-referenced-by-count":13,"title":["Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-0346","authenticated-orcid":true,"given":"Ana Maria","family":"Solans P\u00e9rez de Larraya","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Ortega Molina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Uberos Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, San Cecilio University Hospital, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Roc\u00edo","family":"Gonz\u00e1lez Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, ibs. 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