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To investigate the effect of preoperative treatment and postoperative enhanced anti-inflammatory treatment on alleviating meibomian gland dysfunction (MGD) and dry eye induced by cataract surgery.<jats:italic> Design<\/jats:italic>. Prospective, randomized clinical trial.<jats:italic> Methods<\/jats:italic>. A total of 120 cataract patients with moderate obstructive-MGD were enrolled and randomized with 60:30:30 number of patients in cohorts I, II, and III, respectively: Cohort I: routine postoperative anti-inflammatory treatment; Cohort II: preoperative treatment (warming compress, lid hygiene, and anti-inflammatory treatment) and routine postoperative anti-inflammatory treatment; Cohort III: enhanced postoperative anti-inflammatory treatment.<jats:italic> Main Outcomes Measures<\/jats:italic>. All participants were examined preoperatively and postoperatively for ocular symptom score (OSS), noninvasive keratographic tear break-up time (NIKBUT), corneal fluorescein staining, Schirmer I test, lid margin, meibum quality and expressibility, and meibomian gland dropout.<jats:italic> Results<\/jats:italic>. Ocular surface disorders and MGD showed aggravated status at 1 month postoperatively in Cohort I and Cohort III, and the aggravated MGD resolved by 3 months postoperatively. At 1 month postoperatively, Cohort II and Cohort III presented high NIKBUT and low OSS, lid margin, and meibum quality and expressibility (Cohort II vs Cohort I: all<jats:italic> P<\/jats:italic>&lt;0.001, respectively; Cohort III vs Cohort I:<jats:italic> P<\/jats:italic>=0.011,<jats:italic> P<\/jats:italic>=0.024,<jats:italic> P<\/jats:italic>=0.046,<jats:italic> P<\/jats:italic>=0.045, and<jats:italic> P<\/jats:italic>=0.012, respectively). Additionally, Cohort II had better outcomes of lid margin and meibum quality and expressibility than Cohort III at 1 month postoperatively (<jats:italic>P<\/jats:italic>=0.031,<jats:italic> P<\/jats:italic>=0.026, and<jats:italic> P<\/jats:italic>&lt;0.001, respectively). At 3 months postoperatively, Cohort II presented a significantly higher NIKBUT than Cohort I and Cohort III (<jats:italic>P<\/jats:italic>&lt;0.001 and<jats:italic> P<\/jats:italic>=0.001, respectively).<jats:italic> Conclusion<\/jats:italic>. Preoperative management of MGD is effective and optimal in alleviating obstructive-MGD and dry eye induced by cataract surgery.<\/jats:p>","DOI":"10.1155\/2019\/2737968","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T19:36:32Z","timestamp":1555011392000},"page":"1-10","source":"Crossref","is-referenced-by-count":31,"title":["Preoperative Management of MGD Alleviates the Aggravation of MGD and Dry Eye Induced by Cataract Surgery: A Prospective, Randomized Clinical Trial"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-316X","authenticated-orcid":true,"given":"Peng","family":"Song","sequence":"first","affiliation":[{"name":"Aier School of Ophthalmology, Central South University, Changsha, China"},{"name":"Hankou Aier Eye Hospital, Wuhan, China"},{"name":"Wuhan Aier Eye Institute, Wuhan, 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