{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:34:36Z","timestamp":1747190076405,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2019,10,7]]},"abstract":"<jats:p>Atypical haemolytic uraemic syndrome (aHUS) is a form of thrombotic microangiopathy precipitated by unopposed complement activation, the treatment of which has been revolutionised by the availability of the monoclonal anti-complement (C5) antibody, eculizumab. Historically, women with aHUS would be unable to achieve a successful pregnancy due to the severity of their renal disease and for the few who could conceive, recurrence of aHUS was a significant risk. In spite of this, parenthood remains a priority for many. Experience with eculizumab use in the management of aHUS during pregnancy is growing and with it comes a significant change in the course of the disease. We present the case of a 28-year-old woman diagnosed with severe aHUS in the first trimester of her first pregnancy. She received rescue therapy with eculizumab and had a return to normal renal function. While this pregnancy was lost, she strongly desired a family. We managed her through a subsequent pregnancy while receiving eculizumab. This pregnancy was uncomplicated and carried to term and she birthed a healthy 2500\u2009g baby girl. The complexities of managing a pregnancy in a woman with a history of aHUS are vast but not insurmountable, as demonstrated by this case.<\/jats:p>","DOI":"10.1155\/2019\/2738723","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T19:30:50Z","timestamp":1570476650000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-0035","authenticated-orcid":true,"given":"Samantha","family":"Bateman","sequence":"first","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service (CNARTS), Royal Adelaide Hospital, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maleeka","family":"Ladhani","sequence":"additional","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service (CNARTS), Royal Adelaide Hospital, Adelaide, Australia"},{"name":"Sydney School of Public Health, University of Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpanjali","family":"Jesudason","sequence":"additional","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service (CNARTS), Royal Adelaide Hospital, Adelaide, Australia"},{"name":"School of Medicine, University of Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30062-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070706"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.12.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00280117"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016090995"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.022"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.02.007"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw314"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/2738723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/2738723.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/2738723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T19:30:51Z","timestamp":1570476651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crin\/2019\/2738723\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":9,"alternative-id":["2738723","2738723"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2738723","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"type":"print","value":"2090-6641"},{"type":"electronic","value":"2090-665X"}],"subject":[],"published":{"date-parts":[[2019,10,7]]}}}