{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:34:42Z","timestamp":1747190082858,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:p>Myeloid neoplasm with eosinophilia and FIP1-like-1-platelet-derived growth factor receptor-alpha (FIP1L1-PDGFRA) rearrangement is a multi-organ disease with diverse clinical presentation. Thrombotic thrombocytopenic purpura (TTP) is characterized by the concomitant occurrence of often severe thrombocytopenia, microangiopathic hemolytic anemia, and a variable degree of ischemic organ damage. To our knowledge, only one case of eosinophilia with FIP1L1-PDGFRA rearrangement presented as a case of thrombotic thrombocytopenic purpura reported in the literature. We herein report a case of a young male patient with hypereosinophilic syndrome and FIP1L1-PDGFRA rearrangement who presented with asthma, transient ischemic attacks (TIA), and confusion. He had an acquired TTP that was successfully treated with plasma exchanges (PLEX), corticosteroids, rituximab, and later with the addition of imatinib mesylate (Gleevec, Novartis). He remains in complete remission on imatinib 100\u2009mg daily for more than 28\u2009months of follow-up.<\/jats:p>","DOI":"10.1155\/2019\/2820954","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T19:30:24Z","timestamp":1571167824000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["An Intriguing Case of Eosinophilia with FIP1L1\/PDGFRA Rearrangement Who Presented as Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-068X","authenticated-orcid":true,"given":"Hassan","family":"Alshehri","sequence":"first","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alnomani","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubarak","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Motabi","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-2811","authenticated-orcid":true,"given":"Imran","family":"Tailor","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal","family":"Alshehry","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Alfayez","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"},{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rehman Z.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Altaf","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azizah","family":"AlSwayyed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammar","family":"AlSughayyer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Z. A.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology and BMT, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10328"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2326-9-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06038.x"},{"year":"2008","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24440"},{"year":"2017","key":"6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050054"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0081"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11420"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0787"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.20"},{"issue":"2","key":"12","first-page":"6","volume":"109","year":"2013","journal-title":"The West Virginia Medical Journal"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-709857"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.5482\/hamo-12-10-0016"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20169"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017005124"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018432"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.548"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.326.11274"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2282"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.017"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-37"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.287"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.021675"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2004.03.002"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/2820954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/2820954.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/2820954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T19:30:25Z","timestamp":1571167825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/2820954\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":26,"alternative-id":["2820954","2820954"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2820954","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}