{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:08:41Z","timestamp":1740164921672,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p>A case of bilateral spontaneous chylothorax with respiratory syncytial virus (RSV) bronchiolitis has never been reported. We report the case of a 7-month-old boy born at 33\u2009weeks gestation with a history of Down syndrome, atrial septal defect, pulmonary hypertension, and chronic lung disease, hospitalized due to RSV bronchiolitis who developed bilateral spontaneous chylothorax with exacerbation of pulmonary hypertension (PH). The patient died after 9\u2009weeks of mechanical ventilation and treatment for PH. The autopsy showed acute infectious signs, a chronic interstitial lung disease with pulmonary hypertensive changes and subpleural cysts with no evidence of congenital lymphangiectasia. The cause of chylothorax in this child could be multifactorial. However, worsening pulmonary hypertension with RSV infection might have partially contributed to the development of chylothorax through elevated superior venous cava pressure. Thoracentesis should be considered for patients with Down syndrome and PH associated with congenital heart disease who develop persistent pleural effusion during RSV bronchiolitis to rule out chylothorax.<\/jats:p>","DOI":"10.1155\/2019\/2853632","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T18:30:48Z","timestamp":1549477848000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["A Case of Bilateral Spontaneous Chylothorax with Respiratory Syncytial Virus Bronchiolitis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Mario","family":"Briceno-Medina","sequence":"first","affiliation":[{"name":"Division of Cardiology, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Division of Pediatric Cardiology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronak","family":"Naik","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-8506","authenticated-orcid":true,"given":"Dai","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Le Bonheur Children\u2019s Hospital, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2072"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.104287"},{"issue":"1","key":"3","first-page":"13","volume":"5","year":"2010","journal-title":"Maedica (Buchar)"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb11747.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00594.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198208123070702"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199909000-00042"},{"year":"2012","key":"8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(75)80142-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2007.02296.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33555"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1977.tb00954.x"},{"issue":"1","key":"13","first-page":"49","volume":"20","year":"1984","journal-title":"Anales Espa\u00f1oles de Pediatr\u00eda"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0b013e3181fe4085"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470112"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/2853632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/2853632.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/2853632.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T18:30:49Z","timestamp":1549477849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripe\/2019\/2853632\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":15,"alternative-id":["2853632","2853632"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2853632","relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2019,2,6]]}}}