{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:14:50Z","timestamp":1787127290764,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573003"],"award-info":[{"award-number":["81573003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,23]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic> Cancer cachexia (CCA) is an intractable and ineffective metabolic syndrome that attacks 50\u201380% of cancer patients. It reduces patient\u2019s life quality, affects the efficacy of treatment, and then increases their mortality; however, there are no established therapeutic strategies for CCA in the world. In this study, we assess the positive and negative effects of cannabinoid in the treatment of CCA.<jats:italic> Methods.<\/jats:italic> We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, Web of Science, and PubMed up to December 2017.<jats:italic> Results.<\/jats:italic> Of the 256 screened studies, three studies with a total of 592 participants were included. Compared with placebo, cannabinoid increased the appetite (MD 0.27, 95% CI -0.51 to 1.04; n= 3) but failed to improve the overall quality of life (QOL; MD -12.39, 95% CI [-24.21 to -0.57; n = 2), and a total of 441 patients had 607 adverse events (AEs; 496 in the cannabinoid group and 111 in the placebo group).<jats:italic> Conclusions.<\/jats:italic> Our analysis showed cannabinoid is effective in increasing appetite in cancer patients. However, it declines the quality of life, which may be due to the side effects of cannabinoid.<\/jats:p>","DOI":"10.1155\/2019\/2864384","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T19:31:05Z","timestamp":1561318265000},"page":"1-6","source":"Crossref","is-referenced-by-count":20,"title":["Medical Cannabinoids for Cancer Cachexia: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Tong","sequence":"additional","affiliation":[{"name":"Second Department of Oncology, The Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-8752","authenticated-orcid":true,"given":"Da","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(10)70218-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4467"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21364"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.73644"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<553::AID-CNCR18>3.0.CO;2-0"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1063-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6739-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1995-4"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.07.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008792"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0650"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.09.009"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.06.008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1847"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq727"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(94)00117-4"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2864384.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2864384.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2864384.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T05:39:41Z","timestamp":1568957981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/2864384\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,23]]},"references-count":17,"alternative-id":["2864384","2864384"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2864384","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,23]]}}}