{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:12:31Z","timestamp":1775981551099,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660431"],"award-info":[{"award-number":["81660431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016LX008"],"award-info":[{"award-number":["2016LX008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Human Resources and Social Security Foundation","award":["81660431"],"award-info":[{"award-number":["81660431"]}]},{"name":"Ministry of Human Resources and Social Security Foundation","award":["2016LX008"],"award-info":[{"award-number":["2016LX008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,13]]},"abstract":"<jats:p>Intercellular cell adhesion molecule-1 (ICAM-1), an important adhesion molecule in the immunoglobulin superfamily, is expressed on many cell types. Recent studies have identified ICAM-1 as a potential oncogene that promotes the development of epithelial ovarian cancer (EOC); it was also found to be associated with poor survival. However, the clinical significance of its expression in high-grade serous ovarian carcinoma (HGSOC) is unclear. Thus, this study aimed to investigate the significance of ICAM-1 expression in HGSOC. Data on<jats:italic> ICAM1<\/jats:italic> expression and mutations in serous ovarian carcinoma (SOC) were obtained from the Cancer Genome Atlas (TCGA), and<jats:italic> ICAM1<\/jats:italic> mRNA expression data in HGSOC were obtained from the Gene Expression Omnibus (GEO) database. ICAM-1 expression was evaluated by immunohistochemistry in HGSOC and normal fallopian tube tissues microarray. In TCGA data, amplification\/mutation of<jats:italic> ICAM1<\/jats:italic> was identified in 12% of serous ovarian carcinoma samples, and overexpression of<jats:italic> ICAM1<\/jats:italic> mRNA predicted reduced overall survival in SOC. From TCGA and GEO data, SOC patients with<jats:italic> ICAM1<\/jats:italic> mRNA overexpression treated with chemotherapeutic drugs that contained taxol or taxol and platin together had significantly reduced progression-free survival. According to GEO data,<jats:italic> ICAM1 <\/jats:italic>mRNA expression was found significantly higher in HGSOC than in control samples. In our study, ICAM-1 overexpression was observed in 63.1% (65\/103) of HGSOCs. As a prognostic biomarker, overexpression of ICAM-1 predicted reduced recurrence-free and overall survival and is an independent risk factor for poor prognosis. These findings suggest that overexpression of ICAM-I is an independent indicator of poor prognosis for HGSOC and that it can serve as an effective clinical prognostic biomarker for this disease.<\/jats:p>","DOI":"10.1155\/2019\/2867372","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:30:59Z","timestamp":1560454259000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray"],"prefix":"10.1155","volume":"2019","author":[{"given":"Shasha","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Shihezi University School of Medicine, Xinjiang 832002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shihezi University School of Medicine, Xinjiang 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