{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:58:30Z","timestamp":1756573110020,"version":"3.37.3"},"reference-count":86,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["289850","A1-S-37879","R21-AI120013","IN220316"],"award-info":[{"award-number":["289850","A1-S-37879","R21-AI120013","IN220316"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["289850","A1-S-37879","R21-AI120013","IN220316"],"award-info":[{"award-number":["289850","A1-S-37879","R21-AI120013","IN220316"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["289850","A1-S-37879","R21-AI120013","IN220316"],"award-info":[{"award-number":["289850","A1-S-37879","R21-AI120013","IN220316"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGAPA-PAPIIT-UNAM","award":["289850","A1-S-37879","R21-AI120013","IN220316"],"award-info":[{"award-number":["289850","A1-S-37879","R21-AI120013","IN220316"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:p>Helminth parasites modulate immune responses in their host to prevent their elimination and to establish chronic infections. Our previous studies indicate that <jats:italic>Taenia crassiceps<\/jats:italic>-excreted\/secreted antigens (TcES) downregulate inflammatory responses in rodent models of autoimmune diseases, by promoting the generation of alternatively activated-like macrophages (M2) <jats:italic>in vivo<\/jats:italic>. However, the molecular mechanisms triggered by TcES that modulate macrophage polarization and inflammatory response remain unclear. Here, we found that, while TcES reduced the production of inflammatory cytokines (IL-6, IL-12, and TNF<jats:italic>\u03b1<\/jats:italic>), they increased the release of IL-10 in LPS-induced bone marrow-derived macrophages (BMDM). However, TcES alone or in combination with LPS or IL-4 failed to increase the production of the canonical M1 or M2 markers in BMDM. To further define the anti-inflammatory effect of TcES in the response of LPS-stimulated macrophages, we performed transcriptomic array analyses of mRNA and microRNA to evaluate their levels. Although the addition of TcES to LPS-stimulated BMDM induced modest changes in the inflammatory mRNA profile, it induced the production of mRNAs associated with the activation of different receptors, phagocytosis, and M2-like phenotype. Moreover, we found that TcES induced upregulation of specific microRNAs, including miR-125a-5p, miR-762, and miR-484, which are predicted to target canonical inflammatory molecules and pathways in LPS-induced BMDM. These results suggest that TcES can modulate proinflammatory responses in macrophages by inducing regulatory posttranscriptional mechanisms and hence reduce detrimental outcomes in hosts running with inflammatory diseases.<\/jats:p>","DOI":"10.1155\/2019\/2946713","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:50:18Z","timestamp":1557863418000},"page":"1-24","source":"Crossref","is-referenced-by-count":9,"title":["<i>Taenia crassiceps<\/i>-Excreted\/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages"],"prefix":"10.1155","volume":"2019","author":[{"given":"Diana","family":"Mart\u00ednez-Saucedo","sequence":"first","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Estado de M\u00e9xico, Mexico"},{"name":"Center for Microbial Pathogenesis, The Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan de Dios","family":"Ru\u00edz-Rosado","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, The Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Terrazas","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca E.","family":"Callejas","sequence":"additional","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Partida-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, The Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-9467","authenticated-orcid":true,"given":"Luis I.","family":"Terrazas","sequence":"additional","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Estado de M\u00e9xico, Mexico"},{"name":"Laboratorio Nacional en Salud, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145342"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.04.024"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8494572"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8074329"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/850541"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.11.006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/563425"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/498583"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.11.014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.06.003"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.12703\/p6-13"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.09.003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1017\/s0031182017001652"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408252"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.03.012"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/srep40814"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv403"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.10.024"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426866"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12223"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.9033"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00532"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12127"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-271981"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00332-1"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00716"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00090-5"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201344200"},{"issue":"1","key":"34","first-page":"13","volume":"46","year":"1995","journal-title":"Journal of Inflammation"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.940"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1046-4"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101023"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-106278"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00919-08"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.11.003"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00148"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.054"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-436212"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.7111"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006107200"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7303"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1108702"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1937"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9458-1"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.047"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m115.670661"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506131200"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(90)90169-g"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.6.3020-3025.2002"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.013"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601831113"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0b013e328136c580"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1323"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01062"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1139\/h08-097"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091111"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.4172\/1948-5948.1000276"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5082"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702633200"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903463"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0543-3"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2013.02.001"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1002\/art.27632"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp121"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00098.2015"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-228932"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s127872"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-715"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3616"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4005"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057850"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179543"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24707"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0343-y"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-017-0407-9"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-200"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-018-9760-9"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2009.45"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.02.063"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.145870"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112660108"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6986175"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2016.02.002"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2946713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2946713.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/2946713.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:50:24Z","timestamp":1557863424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2019\/2946713\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":86,"alternative-id":["2946713","2946713"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2946713","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}