{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:54:20Z","timestamp":1776502460286,"version":"3.51.2"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Government","award":["TECH_08-A1-2008-0279"],"award-info":[{"award-number":["TECH_08-A1-2008-0279"]}]},{"name":"Hungarian Government","award":["\u00c1OK-KA-2013\/23"],"award-info":[{"award-number":["\u00c1OK-KA-2013\/23"]}]},{"name":"Hungarian Government","award":["\u00c1OK-KA-2016-SGY"],"award-info":[{"award-number":["\u00c1OK-KA-2016-SGY"]}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["TECH_08-A1-2008-0279"],"award-info":[{"award-number":["TECH_08-A1-2008-0279"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["\u00c1OK-KA-2013\/23"],"award-info":[{"award-number":["\u00c1OK-KA-2013\/23"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["\u00c1OK-KA-2016-SGY"],"award-info":[{"award-number":["\u00c1OK-KA-2016-SGY"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["TECH_08-A1-2008-0279"],"award-info":[{"award-number":["TECH_08-A1-2008-0279"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["\u00c1OK-KA-2013\/23"],"award-info":[{"award-number":["\u00c1OK-KA-2013\/23"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["\u00c1OK-KA-2016-SGY"],"award-info":[{"award-number":["\u00c1OK-KA-2016-SGY"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,1,3]]},"abstract":"<jats:p><jats:italic>Campylobacter jejuni<\/jats:italic>is one of the most common food-borne bacteria that causes gastrointestinal symptoms. In the present study we have investigated the molecular basis of the anti-<jats:italic>Campylobacter<\/jats:italic>effect of peppermint essential oil (PEO), one of the oldest EO used to treat gastrointestinal diseases. Transcriptomic, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and proteomic, two-dimensional polyacryl amid gel electrophoresis (2D-PAGE) methods have revealed that, in the presence of a sublethal concentration of PEO, the expression of several virulence-associated genes was decreased (<jats:italic>cheY<\/jats:italic>0.84x;<jats:italic>flhB<\/jats:italic>0.79x;<jats:italic>flgE<\/jats:italic>0.205x;<jats:italic>cadF<\/jats:italic>0.08x;<jats:italic>wlaB<\/jats:italic>0.89x;<jats:italic>porA<\/jats:italic>0.25x;<jats:italic>cbf2<\/jats:italic>4.3x) while impaired motility was revealed with a functional analysis. Scanning electron micrographs of the exposed cells showed that, unlike in the presence of other stresses, the originally curved<jats:italic>C. jejuni<\/jats:italic>cells straightened upon PEO exposure. Gaining insight into the molecular background of this stress response, we have revealed that in the presence of PEO<jats:italic>C. jejuni<\/jats:italic>dominantly exerts a general stress response that elevates the expression of general stress genes like<jats:italic>dnaK<\/jats:italic>,<jats:italic>groEL<\/jats:italic>,<jats:italic>groES<\/jats:italic>(10.41x, 3.63x, and 4.77x). The most important genes<jats:italic>dps<\/jats:italic>,<jats:italic>sodB<\/jats:italic>, and<jats:italic>katA<\/jats:italic>involved in oxidative stress responses showed however moderate transcriptional elevations (1,58x, 1,55x, and 1,85x).<\/jats:p>","DOI":"10.1155\/2019\/2971741","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T23:31:27Z","timestamp":1546558287000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil in<i>Campylobacter jejuni<\/i>"],"prefix":"10.1155","volume":"2019","author":[{"given":"J. K.","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fels\u0151","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy.","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1.","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"\u00c1brah\u00e1m","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Central Electron Microscope Laboratory, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Nanophagetherapy Center, Enviroinvest Corporation, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"M\u00e1rk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Em\u0151dy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of P\u00e9cs Medical School, Hungary"},{"name":"Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-8136","authenticated-orcid":true,"given":"T.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Nanophagetherapy Center, Enviroinvest Corporation, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-7585","authenticated-orcid":true,"given":"Gy.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of P\u00e9cs Medical School, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2014.3547"},{"key":"2","first-page":"121","volume-title":"Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations","year":"2000"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1605(91)90043-O"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.4031771.x"},{"issue":"25","key":"5","doi-asserted-by":"crossref","first-page":"18717","DOI":"10.1016\/S0021-9258(17)46689-0","volume":"268","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2007.00893.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.677.2006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00898-09"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.603743"},{"issue":"24","key":"10","volume":"83","year":"2017","journal-title":"Applied and Environmental Microbiology"},{"issue":"47","key":"11","volume":"5","year":"2017","journal-title":"Genome Announcements"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03035.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7391"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01221-16"},{"key":"16","first-page":"1036","volume":"3","year":"2015","journal-title":"JSM Gastroenterol. Hepatol"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/718645"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765X.1998.00303.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-65.10.1545"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2008.0100"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.03.022"},{"key":"22","first-page":"176","year":"2003","journal-title":"Natural Antimicrobials for the Minimal Processing of Foods"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1021\/jf900668n"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/35001088"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2006.03.015"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00403-5"},{"key":"27","first-page":"4643","volume":"64","year":"1988","journal-title":"Applied and Environmental Microbiology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1998.00532.x"},{"issue":"2","key":"29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/AEM.64.2.733-741.1998","volume":"64","year":"1998","journal-title":"Applied and Environmental Microbiology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-69.11.2747"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1128\/aem.02149-10"},{"key":"32","first-page":"1801","volume":"58","year":"1986","journal-title":"Applied and Environmental Microbiology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.1.711-714.2003"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2007.03.004"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01399-06"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.14-23.2001"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.9.e36"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02903.x"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-160"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02762.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/0969-2126(93)90007-4"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01647-07"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.19.7139"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00100-08"},{"key":"45","year":"2001"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2016.09.027"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.02.136"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13315"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.9.2937-2942.2001"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401134200"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/681754"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2009.05.002"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1264\/jsme2.ME14020"},{"key":"54","volume":"6","year":"2015","journal-title":"Frontiers in Microbiology"},{"key":"55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2180-11-207","volume":"11","year":"2011","journal-title":"BMC Microbiology"},{"issue":"5","key":"56","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1128\/AEM.63.5.1826-1837.1997","volume":"63","year":"1997","journal-title":"Applied and Environmental Microbiology"},{"issue":"16","key":"57","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1128\/JB.181.16.4798-4804.1999","volume":"181","year":"1999","journal-title":"Journal of Bacteriology"},{"issue":"1","key":"58","volume":"9","year":"2014","journal-title":"PLoS ONE"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1838"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01975-05"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2008.01768.x"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520100219"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2008.10.004"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2971741.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2971741.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2971741.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T17:57:34Z","timestamp":1662746254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/2971741\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":64,"alternative-id":["2971741","2971741"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2971741","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]}}}