{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:32:24Z","timestamp":1771061544421,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Research Fund of Xinqiao Hospital of Third Military Medical University","award":["2014YlC12"],"award-info":[{"award-number":["2014YlC12"]}]},{"name":"Clinical Research Fund of Xinqiao Hospital of Third Military Medical University","award":["2015A497"],"award-info":[{"award-number":["2015A497"]}]},{"name":"Starting Fund for Talents Returning from Overseas of Ministry of Education","award":["2014YlC12"],"award-info":[{"award-number":["2014YlC12"]}]},{"name":"Starting Fund for Talents Returning from Overseas of Ministry of Education","award":["2015A497"],"award-info":[{"award-number":["2015A497"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,24]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Response to cardiac resynchronization therapy (CRT) varies significantly among patients. This study aimed to identify baseline characteristics that could predict super-response to CRT and to evaluate the long-term prognosis in super-responders.<jats:italic> Methods<\/jats:italic>. We retrospectively reviewed the data of 73 consecutive patients who received CRT. Patients were considered as super-responders after 6-month follow-up when NYHA class reduction to I or II combined with left ventricular ejection fraction (LVEF) \u2265 50% was observed. Patients were divided into super-responders group and non-super-responders group. All-cause mortality or hospitalization for heart failure (HF) was referred to the combined end point.<jats:italic> Results<\/jats:italic>. 17 (23.3%) patients were super-responders. HF duration, left atrial dimension (LAD), and left bundle branch block (LBBB) were independent predictors of super-response to CRT. The combination of HF duration and LAD could provide more robust prediction of super-response than standalone HF duration (0.899 versus 0.789, Z = 2.207, P = 0.027) or standalone LAD (0.899 versus 0.775, Z = 2.487, P = 0.013). super-responders had excellent LV reverse remodeling. The cumulative incidences of combined end point were significantly lower in the super-responders group, LAD \u2264 42mm group, and combination of HF duration \u2264 48 months and LAD \u2264 42mm group. LBBB remained associated with a lowered risk of the combined end point (HR: 0.19, 95% CI: 0.07-0.57, P = 0.003), whereas LAD was associated with a raised risk of the combined end point (HR: 1.09, 95% CI: 1.02-1.17, P = 0.014).<jats:italic> Conclusions<\/jats:italic>. HF duration, LAD, and LBBB independently predicted super-response. The combination of HF duration and LAD makes more robust prediction of CRT super-response. Super-responders had excellent LV reverse remodeling and decreased the incidences of the combined end point. LBBB and LAD were independently associated with the combined end point.<\/jats:p>","DOI":"10.1155\/2019\/2983752","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T08:53:42Z","timestamp":1561452822000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation"],"prefix":"10.1155","volume":"2019","author":[{"given":"Zhinian","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-4228","authenticated-orcid":true,"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61228-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962605"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux235"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22658"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.065"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp368"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.074"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus075"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.hrthm.2008.04.015","volume":"5","year":"2008","journal-title":"Heart Rhythm"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup035"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.10.028"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02305-7"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00163-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb02544.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup038"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118502.91105.F6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.04.005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut049"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300222"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02018.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2014.01.017"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.03.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2983752.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2983752.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/2983752.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T08:53:52Z","timestamp":1561452832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/2983752\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,24]]},"references-count":23,"alternative-id":["2983752","2983752"],"URL":"https:\/\/doi.org\/10.1155\/2019\/2983752","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,24]]}}}