{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:38:31Z","timestamp":1774535911824,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:p><jats:italic>Background and Aim. <\/jats:italic>To develop a noninvasive magnetic resonance imaging (MRI) method for evaluation of liver fibrosis. We evaluate the utility of hepatocyte-phase Gadoxetate disodium\u2013enhanced magnetic resonance (MR) imaging in staging hepatic fibrosis and compare it with histological analysis as the reference standard (liver biopsy).<jats:italic> Methods. <\/jats:italic>Prospective cohort of 78 patients, who received Gadoxetate disodium dynamic contrast-enhanced MRI (DCE-MRI), were divided into three groups. The first group (n=19) was a control group of healthy individuals without liver injury and remaining 59 subjects were chronic hepatitis B and C patients who underwent liver biopsy. These patients were divided into the mild fibrosis F1-F2 (n=32) and advanced fibrosis F3-F4 (n=27) groups. Patients were examined by generated DCE-MRI in 20th minute. Variables such as liver surface changes, homogeneities, and quantitative contrast liver\/spleen ratio-Q-LSCR were evaluated and these results were consequently compared between the three groups.<jats:italic> Results. <\/jats:italic>Gd-EOB-DTPA contrast-enhanced dynamic liver MRI examination (DCE-MRI) can in the 20th minute differentiate mild stage of liver fibrosis (F1-F2) from severe stage of liver fibrosis (F3-F4) on the basis of liver surface changes, homogeneities, and quantitative contrast liver\/spleen ratio-Q-LSCR. Diagnostic MRI criteria were created and named MRI Triple test. This test correctly identified 96% of patients with F3-F4 fibrosis and 91% of patients with the F1-F2 fibrosis in the liver biopsy. This test correctly identified 42,1% of patients in the control group (presumed F0 fibrosis without liver disease). Spearman's rank correlation coefficient (r = 0,86, P &lt; .001) confirmed high agreement of biopsy and MR Triple test. MR Triple test\u2019s sensitivity was 96.30% (95%CI 81.03% to 99.91%), specificity 90.62% (95%CI 74.98% to 98.02%), positive predictive value 89.66% (95%CI 74.64% to 96.23%), and negative predictive value 96.67% (95%CI 80.86% to 99.50%) for discrimination between F3-4 and F1-2 fibrosis on liver biopsy.<jats:italic> Conclusions. <\/jats:italic>Gd-EOB-DTPA contrast-enhanced MRI liver examination in 20th minute is able to reliably differentiate mild stage of liver fibrosis (F1-F2) from severe stage fibrosis (F3-F4) on the basis of Triple test (liver surface changes, homogeneities, and quantitative contrast liver\/spleen ratio-Q-LSCR).<\/jats:p>","DOI":"10.1155\/2019\/3024630","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T19:32:05Z","timestamp":1554147125000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B or C by Contrast-Enhanced Magnetic Resonance Imaging"],"prefix":"10.1155","volume":"2019","author":[{"given":"Ren\u00e9","family":"Hako","sequence":"first","affiliation":[{"name":"Department of Radiology, General Hospital ZZKE, Ko\u0161ice 04001, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-1355","authenticated-orcid":true,"given":"Pavol","family":"Kristian","sequence":"additional","affiliation":[{"name":"Department of Infectology and Travel Medicine, Faculty of Medicine, University of P. J. Safarik, Ko\u0161ice 04001, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-9984","authenticated-orcid":true,"given":"Peter","family":"Jar\u010du\u0161ka","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Faculty of Medicine, University of P. J. Safarik, Ko\u0161ice 04001, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Hakov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital, Trebi\u0161ov 04001, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Hockickov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Infectology and Travel Medicine, Faculty of Medicine, University of P. J. 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