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Vitamin D plays an important role in water and salt homeostasis. The aim of our study was to investigate the underlying relationship of Vitamin D and Aquaporins (AQP).<jats:italic> Methods<\/jats:italic>. The behaviors of 1<jats:italic>\u03b1<\/jats:italic> (OH)-ase knockout mice and wild type mice were observed before analysis. The ICR mice were treated with vehicle or paricalcitol, a vitamin D analogue, followed by animals receiving a standard diet and free access to drinking water either with aliskiren (renin blocker; 37.5\u2009mg aliskiren in 100\u2009ml water), or telmisartan (a angiotensin II type I receptor blocker; 40\u2009mg telmisartan in 100\u2009ml water) a week before study. The expressions of AQP-1, AQP-4, and renin in mice kidneys were detected by western bolting, immunohistochemistry, and immunofluorescence.<jats:italic> Results<\/jats:italic>. Diuresis and polydipsia were observed in 1<jats:italic>\u03b1<\/jats:italic> (OH)-ase knockout mice, and a decreased water intake and urine output in ICR mice was observed after paricalcitol treatment. Compared with wild type, the AQP-1 expressions were increased in renal papilla and AQP-4 expressions were decreased in renal proximal tubule of 1<jats:italic>\u03b1<\/jats:italic>(OH) ase knockout mice. In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. After injecting renin into the lateral ventricle of the 1<jats:italic>\u03b1<\/jats:italic>(OH)ase knockout mice, the renin expression level was decreased in the kidney, followed by the decrease of AQP-1 in renal papilla and increase of AQP-4 in proximal tubule.<jats:italic> Conclusions<\/jats:italic>. Overall, Vitamin D and renin inhibitors have synergistic effects in regulating water channels in mice kidneys.<\/jats:p>","DOI":"10.1155\/2019\/3027036","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T18:30:48Z","timestamp":1548613848000},"page":"1-7","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys"],"prefix":"10.1155","volume":"2019","author":[{"given":"Yu","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Shengjing Hospital, China Medical University, No. 36 Sanhao St., Heping District, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Fourth Affiliated Hospital, China Medical University, No. 4 Chongshan Dong Road, Huanggu District, Shenyang, 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