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Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone. This was approached both <jats:italic>in silico<\/jats:italic> using molecular docking against glucocorticoid receptor (GR) and <jats:italic>in vivo<\/jats:italic> in two different animal models. All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar <jats:italic>in vivo<\/jats:italic> anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> in cotton pellet-induced granuloma in rats. In addition, both compounds significantly decreased the percent of change in ear weight in croton oil-induced ear edema in mice and the granuloma weight in cotton pellet-induced granuloma in rats, to levels comparable to that of fluticasone. Both boswellic acid and withaferin A had no effect on adrenal index, but only withaferin A significantly increased the thymus index. In conclusion, boswellic acid may have comparable anti-inflammatory effects to fluticasone with fewer side effects.<\/jats:p>","DOI":"10.1155\/2019\/3041438","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T19:30:34Z","timestamp":1558985434000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-9094","authenticated-orcid":true,"given":"Mohamed A.","family":"Morsy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia"},{"name":"Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-7530","authenticated-orcid":true,"given":"Snehal S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0386","authenticated-orcid":true,"given":"Azza A. 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