{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T05:12:35Z","timestamp":1784437955822,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty Construction Project Funding","award":["(2011) 170"],"award-info":[{"award-number":["(2011) 170"]}]},{"name":"National Key Clinical Specialty Construction Project Funding","award":["2017-510"],"award-info":[{"award-number":["2017-510"]}]},{"name":"Fujian Province Intensive Medical Center Construction Project","award":["(2011) 170"],"award-info":[{"award-number":["(2011) 170"]}]},{"name":"Fujian Province Intensive Medical Center Construction Project","award":["2017-510"],"award-info":[{"award-number":["2017-510"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Urosepsis and septic shock are a critical situation leading to a mortality rate up to 30% in patients with obstructive diseases of the urinary tract.<jats:italic> Aim.<\/jats:italic> To analyze the bacterial distribution and drug resistance of pathogenic bacteria in patients with urosepsis and to provide a basis for the rational application of antibacterial drugs in clinical practice.<jats:italic> Methods.<\/jats:italic> A retrospective analysis of 94 hospitalized patients with urosepsis for 6 years was performed. The strain composition, resistance characteristics, and the antibiogram of common bacteria from positive blood and midstream urine culture were analyzed.<jats:italic> Results.<\/jats:italic> A total of 87 strains were isolated, including 65 strains (74.71%) of Gram-negative bacilli, 14 strains (16.09%) of Gram-positive cocci, and 8 strains (9.20%) of fungi. The Gram-negative bacilli included 42 strains of<jats:italic> Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) (64.62%), among which 34 strains (80.95%) were producing ESBLs, and 14 strains (21.84%) of<jats:italic> Klebsiella pneumoniae<\/jats:italic> (<jats:italic>K. pneumoniae<\/jats:italic>), among which nine strains (64.29%) were producing ESBLs. The most common pathogenic bacteria, ESBL+<jats:italic> E. coli<\/jats:italic> and<jats:italic> K. pneumoniae<\/jats:italic> strains, showed sensitivity towards imipenem, ertapenem, piperacillin\/tazobactam, amikacin, and cefotetan, but were highly resistant to quinolones. The cure rate of urosepsis was 88.30%, and the susceptibility rate of septic shock was 45.47%.<jats:italic> Significance.<\/jats:italic> Gram-negative bacterial infections are the main cause of urosepsis. The mild patient group showed more<jats:italic> E. coli<\/jats:italic> (ESBL-) infections, and the number of ESBL producing<jats:italic> E. coli<\/jats:italic> isolated from the mild group showed higher drug resistance rates for aztreonam and levofloxacin compared with isolates from the severe group.<\/jats:p>","DOI":"10.1155\/2019\/3080827","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T18:30:49Z","timestamp":1549477849000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Situations of Bacteriology and Prognosis in Patients with Urosepsis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Ying","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlan","family":"Hu","sequence":"additional","affiliation":[{"name":"Microbiology Department of Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-6733","authenticated-orcid":true,"given":"Xiuling","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-6821","authenticated-orcid":true,"given":"Rongguo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgical Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Clinical Teaching Hospital Affiliated to the Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2012.0331"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1236-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.02.019"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.12891\/ceogl945.2015"},{"key":"5","year":"2018","journal-title":"BJU International"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-016-0859-8"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9028924"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12608"},{"key":"9","year":"2017","journal-title":"European Association of Urology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746040-00003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20328"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0275OC"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.057"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2015.0837"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1353-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/2047-2994-3-23"},{"issue":"6","key":"17","first-page":"694","volume":"12","year":"2016","journal-title":"Chinese Journal of Infection and Chemotherapy"},{"key":"18","year":"2017","journal-title":"The Society of Critical Care Medicine"},{"issue":"24","key":"19","first-page":"1856","volume":"94","year":"2014","journal-title":"National Medical Journal of China"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2013.08.006"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1086\/604713"},{"key":"22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1086\/649537","volume":"50","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06002-11"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.213407"},{"key":"25","first-page":"79","volume":"17","year":"2018","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2174\/092986706776873023"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.19272v2"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3080827.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3080827.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3080827.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T18:30:53Z","timestamp":1549477853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/3080827\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":27,"alternative-id":["3080827","3080827"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3080827","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]}}}