{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:51:52Z","timestamp":1778910712517,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2019,12,30]]},"abstract":"<jats:p>Chronic inflammation induced by <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection plays a major role in development of gastric cancer. However, recent findings suggested that progression of inflammation and neoplastic transformation in <jats:italic>H. pylori<\/jats:italic> infection are more complex than previously believed and could involve different factors that modulate gastric microenvironment and influence host-pathogen interaction. Among these factors, gastric myenteric plexus and its potential adaptive changes in H. pylori infection received little attention. This study is aimed at identifying the impact of <jats:italic>H. pylori<\/jats:italic>-associated gastritis on number and morphology of nerve cells in the stomach. The distribution of density, inflammation, and programmed cell death in neurons was immunohistochemically assessed in full-thickness archival tissue samples obtained from 40 patients with <jats:italic>H. pylori<\/jats:italic> infection who underwent surgery for gastric cancer and were compared with findings on samples collected from 40 age- and sex-matched subjects without bacteria. Overall, significant differences were noted between <jats:italic>H. pylori<\/jats:italic>-positive and <jats:italic>H. pylori<\/jats:italic>-negative patients. The analysis of tissue specimens obtained from those with infection revealed higher density and larger surface of the myenteric nervous plexus, as well as a significant increase in the number of gastric neuronal cell bodies and glial cells compared to controls. A predominant CD3-immunoreactive T cell infiltrate confined to the myenteric plexus was observed in infected subjects. The presence of mature B lymphocytes, plasma cells, and eosinophils was also noted, but to a lesser extent, within the ganglia. Myenteric ganglionitis was associated with degeneration and neuronal loss. Our results represent the first histopathological evidence supporting the hypothesis that <jats:italic>H. pylori<\/jats:italic>-induced gastric inflammation may induce morphological changes in myenteric gastric ganglia. These findings could help gain understanding of some still unclear aspects of pathogenesis of <jats:italic>H. pylori<\/jats:italic> infection, with the possibility of having broader implications for gastric cancer progression.<\/jats:p>","DOI":"10.1155\/2019\/3085181","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:30:50Z","timestamp":1577730650000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-4012","authenticated-orcid":true,"given":"Liana","family":"Sticlaru","sequence":"first","affiliation":[{"name":"Pathology Department, Colentina University Hospital, Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, 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