{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:09:34Z","timestamp":1789639774440,"version":"4.0.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,2,4]]},"abstract":"<jats:p>To investigate whether serum leucine-rich<jats:italic>\u03b1<\/jats:italic>2-glycoprotein (LRG) levels are useful as a marker of disease activity in systemic juvenile idiopathic arthritis (s-JIA), we determined serum LRG levels in fifty-nine s-JIA patients, 15 with other subtypes of JIA, 7 with Kawasaki disease (KD), 7 with influenza A infection (flu), 7 with enterohemorrhagic<jats:italic>Escherichia coli<\/jats:italic>(EHEC) infection, and 20 healthy controls (HC). Results were compared with the clinical features of s-JIA and serum cytokine levels including interleukin- (IL-) 6, IL-18, and soluble tumor necrosis factor receptors I and II. Serum LRG levels in active s-JIA were higher compared to those in other subtypes of JIA, EHEC, flu patients, and HC. Serum LRG levels were normalized in the inactive s-JIA phase after treatment. Serum LRG levels were positively correlated with serum C-reactive protein and ferritin levels. Serum LRG levels reflected s-JIA disease activity and thus may be useful for monitoring s-JIA disease activity.<\/jats:p>","DOI":"10.1155\/2019\/3140204","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:35:19Z","timestamp":1549323319000},"page":"1-6","source":"Crossref","is-referenced-by-count":20,"title":["Serum Leucine-Rich<i>\u03b1<\/i>2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-7772","authenticated-orcid":true,"given":"Masaki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Nakagishi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children\u2019s Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yachie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.68"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1349-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nature12345"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1189\/jlb.72.3.478","volume":"72","year":"2002","journal-title":"Journal of Leukocyte Biology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22936"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118919"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/art.39164"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1016103"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.104"},{"issue":"2","key":"10","first-page":"390","volume":"31","year":"2004","journal-title":"The Journal of Rheumatology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/art.39332"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2182"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/srep43732"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1270795"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.02.006"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3140204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3140204.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3140204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:31:16Z","timestamp":1694604676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2019\/3140204\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":16,"alternative-id":["3140204","3140204"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3140204","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]}}}