{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:24:23Z","timestamp":1768260263250,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,11]]},"abstract":"<jats:p><jats:italic>Lopezia racemosa<\/jats:italic>Cav<jats:italic>.<\/jats:italic>(Onagraceae) has been used in Mexican traditional medicine to alleviate stomachache, biliary colic, urine retention, stomach cancer, and skin, dental, buccal, and urinary infections. The objective of this study was to determine the bioactivities of specific parts of the plant to scientifically confirm its traditional use. Aerial parts and flowers were macerated and subsequently extracted with hexane, chloroform, and methanol. This study was focused on the analysis of polar components, and thus the methanolic fractions were selected for further investigations. These fractions were evaluated for their antimicrobial activity using a panel of bacterial Gram-positive and -negative strains, as well as fungal strains, including filamentous fungi and yeasts. In addition, the cytotoxic activity of the extract was assessed by MTT using the human-derived monocytic THP-1 and the normal human fibroblast cell lines. Various fractions showed antimicrobial activity against various pathogens, although the most relevant were against<jats:italic>Pseudomonas aeruginosa<\/jats:italic>and<jats:italic>Trichophyton mentagrophytes<\/jats:italic>. No inhibition of yeasts was recorded. Only four fractions showed cytotoxic effects when the human-derived THP-1 and fibroblast cells were assessed. The four flavonoids isolated from the extract were luteolin, luteolin-6-C-hexoside, luteolin-8-C-hexoside, and hyperoside. The biological activities presented in this study validate some traditional uses of the plant.<\/jats:p>","DOI":"10.1155\/2019\/3286489","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:40:51Z","timestamp":1555026051000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Bioactivities of Flavonoids from<i>Lopezia racemosa<\/i>"],"prefix":"10.1155","volume":"2019","author":[{"given":"Enrique","family":"Vergara Barrag\u00e1n","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-9299","authenticated-orcid":true,"given":"Horacio","family":"Bach","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Socorro","family":"Meza-Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Montiel-Smith","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-7631","authenticated-orcid":true,"given":"Eugenio","family":"S\u00e1nchez-Arreola","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad de las Am\u00e9ricas Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-1244","authenticated-orcid":true,"given":"Luis Ricardo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmico Biol\u00f3gicas, Universidad de las Am\u00e9ricas Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8339.1993.tb01893.x"},{"key":"2","year":"2003"},{"issue":"42","key":"5","first-page":"215","year":"2016","journal-title":"Polibot\u00e1nica"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/237438"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19068679"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88458-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.071"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.04.058"},{"issue":"4","key":"11","first-page":"321","volume":"57","year":"2000","journal-title":"Acta Poloniae Pharmaceutica. 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