{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:51:48Z","timestamp":1786416708538,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["2019322028"],"award-info":[{"award-number":["2019322028"]}]},{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["2018254219"],"award-info":[{"award-number":["2018254219"]}]},{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["81800476"],"award-info":[{"award-number":["81800476"]}]},{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["2019322028"],"award-info":[{"award-number":["2019322028"]}]},{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["2018254219"],"award-info":[{"award-number":["2018254219"]}]},{"name":"Zhejiang Provincial Medical and Healthy Science and Technology Projects","award":["81800476"],"award-info":[{"award-number":["81800476"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019322028"],"award-info":[{"award-number":["2019322028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018254219"],"award-info":[{"award-number":["2018254219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800476"],"award-info":[{"award-number":["81800476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:p>Functional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism. Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility. PubMed, EMBASE, the Cochrane Library, and HuGE database were searched. An additive model was adopted to determine whether previous studied genes are associated with FD susceptibility. Carriers of minor allele in GNB3 825C&gt;T (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.15<\/mml:mn><\/mml:math>, 95% CI 0.99-1.34, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.07<\/mml:mn><\/mml:math>), SCL6A4 5HTTLPR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.92<\/mml:mn><\/mml:math>, 95% CI 0.75-1.12, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.40<\/mml:mn><\/mml:math>), and CCK-1R 779T&gt;C (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.86<\/mml:mn><\/mml:math>, 95% CI 0.72-1.03, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.09<\/mml:mn><\/mml:math>) genes failed to demonstrate susceptibility to FD. In a subgroup analysis, only minor allele (T) in GNB3 825C&gt;T was associated with an increased susceptibility to the epigastric pain syndrome subtype (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.34<\/mml:mn><\/mml:math>, 95% CI 1.10-1.63, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>). Our meta-analysis based on available studies using an additive model failed to show that GNB3, SCL6A4, and CCK-1R polymorphisms are associated with FD susceptibility.<\/jats:p>","DOI":"10.1155\/2019\/3420548","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T19:34:19Z","timestamp":1555356859000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-1959","authenticated-orcid":true,"given":"Lijun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Loma Linda University Health, Loma Linda, CA 92354, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binrui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"},{"name":"Ningbo City Medical Treatment Center Lihuili Hospital, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(04)00082-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90783-H"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000740"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40052.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4065\/75.9.907"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01320.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v4.i2.28"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.206"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15138"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701742930"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.09-31"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3163"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b5745e"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008015"},{"issue":"86-87","key":"19","first-page":"1921","volume":"55","year":"2008","journal-title":"Hepatogastroenterology"},{"issue":"84","key":"20","first-page":"979","volume":"55","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-017-0788-7"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2886-4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-013-0269-3"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0602-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9925-y"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00371.2007"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.8662"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32830e2871"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-40"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.20.5.717"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2007.0720"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.006"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2014.8.3.271"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00481.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12596"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000000511"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.139"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.2.205"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-13"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01781.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9923-0"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12913"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01102.x"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14086"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-88"},{"issue":"93","key":"46","first-page":"1245","volume":"56","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/358424a0"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283491153"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2016.1210621"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02339-0"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3057-y"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5037254"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.15"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.007"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.15171\/mejdd.2016.48"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.190936"},{"issue":"3","key":"57","first-page":"237","volume":"15","year":"2006","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00941.x"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.07.001"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1452912"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66062621.x"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1124\/mi.4.2.8"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.347"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i9.1329"},{"issue":"1","key":"65","first-page":"1","volume":"52","year":"2003","journal-title":"Physiological Research"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119492"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3731.80"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH688>3.0.CO;2-D"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.219"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00039-3"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/3420548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/3420548.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/3420548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T19:34:27Z","timestamp":1555356867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2019\/3420548\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":70,"alternative-id":["3420548","3420548"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3420548","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]}}}