{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:11:46Z","timestamp":1786227106661,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790641"],"award-info":[{"award-number":["81790641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201840050"],"award-info":[{"award-number":["201840050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010032","name":"Foundation of Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["81790641"],"award-info":[{"award-number":["81790641"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010032","name":"Foundation of Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["201840050"],"award-info":[{"award-number":["201840050"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,5,9]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate platelet parameters in primary open-angle glaucoma (POAG) patients and to explore the association between platelet parameters and POAG severity. <jats:italic>Methods<\/jats:italic>. A total of 402 consecutive POAG patients and 408 healthy control subjects from the Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Fudan University, were consecutively recruited between January 2016 and October 2018. Detailed ophthalmological and systematic examinations were performed. Blood samples for platelet parameters, including platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR), were analyzed using an automated hematology analyzer in the department of clinical laboratory science of the hospital. The POAG subgroups were classified according to age (&lt;50, \u226550), gender, and visual field mean deviation (MD): mild (MD\u2009\u2264\u20096\u2009dB), moderate (6\u2009dB\u2009&lt;\u2009MD\u2009\u2264\u200912\u2009dB), and severe (MD\u2009&gt;\u200912\u2009dB). <jats:italic>Results<\/jats:italic>. In POAG patients, PLT counts (207.08\u2009\u00b1\u200954.70\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>\u2217<\/mml:mi><\/mml:math>\u200910<jats:sup>9<\/jats:sup>\/L) were significantly lower <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math> than those of the control group (220.46\u2009\u00b1\u200955.85\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>\u2217<\/mml:mi><\/mml:math>\u200910<jats:sup>9<\/jats:sup>\/L). In the POAG group, PDW (13.76\u2009\u00b1\u20093.16\u2009fL) and MPV (10.46\u2009\u00b1\u20091.32\u2009fL) values were significantly higher (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) than those of the control group (PDW 11.82\u2009\u00b1\u20092.44\u2009fL, MPV 10.13\u2009\u00b1\u20091.10\u2009fL). PDW and MPV values were highest in the severe POAG group (PDW 14.49\u2009\u00b1\u20092.99\u2009fL; MPV 10.74\u2009\u00b1\u20091.39\u2009fL), followed by the moderate group (PDW 12.50\u2009\u00b1\u20093.14\u2009fL; MPV 10.02\u2009\u00b1\u20091.08\u2009fL) and then the mild group (PDW 11.82\u2009\u00b1\u20092.44\u2009fL; MPV 9.92\u2009\u00b1\u20090.76\u2009fL), with statistically significant differences observed between mild-severe POAG and moderate-severe POAG groups by LSD post hoc test. Multiple linear regression analyses showed a significant association between PDW and MD (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.430, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and MPV and MD (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.363, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Logistic regression analyses revealed that PDW (OR\u2009=\u20091.297, 95% CI\u2009=\u20091.011\u20131.663) was associated with the severity of POAG. <jats:italic>Conclusions<\/jats:italic>. PDW and MPV values were significantly elevated in POAG patients, and PDW was positively associated with disease severity, which suggested the possibility that platelet activation be involved in pathomechanisms of POAG.<\/jats:p>","DOI":"10.1155\/2019\/3425023","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T19:30:52Z","timestamp":1557430252000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-4809","authenticated-orcid":true,"given":"Yi","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"},{"name":"Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 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