{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:30:07Z","timestamp":1771993807010,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,3,25]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Statin-associated muscle symptoms are common side effects of statin therapy. These symptoms include myopathy, myalgia, and rhabdomyolysis. Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue. Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it. <jats:italic>Patients and Methods<\/jats:italic>. This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status. These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS. <jats:italic>Results<\/jats:italic>. We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS). Vitamin D deficiency (&lt;30\u2009nmol\/L) presents 77% (95% C.I. 71.6% to 81.7%) sensitivity and 63.4% (95% C.I. 60.2% to 66.5%) specificity in diagnosing SAMS. Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status. <jats:italic>Conclusion<\/jats:italic>. We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.<\/jats:p>","DOI":"10.1155\/2019\/3549402","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:31:14Z","timestamp":1553542274000},"page":"1-6","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-1411","authenticated-orcid":true,"given":"Manuela","family":"Pennisi","sequence":"first","affiliation":[{"name":"Spinal Unit, Emergency Hospital Cannizzaro, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Di Bartolo","sequence":"additional","affiliation":[{"name":"Research Center \u201cThe Great Senescence\u201d, University of Catania, 95100 Catania, 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