{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:07:36Z","timestamp":1791814056395,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. <jats:italic>Methods<\/jats:italic>. In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of \u226520\/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup\/disc ratio, and rim area. <jats:italic>Results<\/jats:italic>. A total of 31 patients met the inclusion criteria and were included in the study: 16 with suprasellar tumors and 15 with POAG. Both groups were similar in terms of gender and age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). The glaucoma group had a borderline greater total RNFL thickness (74.2\u2009<jats:italic>\u03bc<\/jats:italic>m versus 62.8\u2009<jats:italic>\u03bc<\/jats:italic>m, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.07<\/mml:mn><\/mml:mrow><\/mml:math>), disc area (2.70\u2009mm<jats:sup>2<\/jats:sup> versus 2.16\u2009mm<jats:sup>2<\/jats:sup>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:mrow><\/mml:math>), and cup volume (0.20\u2009mm<jats:sup>3<\/jats:sup> versus 0.08\u2009mm<jats:sup>3<\/jats:sup>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:mrow><\/mml:math>). In multivariate, glaucoma was associated with increased total RNFL thickness (OR\u2009=\u20091.116 per <jats:italic>\u03bc<\/jats:italic>m, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:mrow><\/mml:math>), increased disc area (OR\u2009=\u20092.402 per 100\u2009<jats:italic>\u03bc<\/jats:italic>m<jats:sup>2<\/jats:sup>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>), and decreased rim area (OR\u2009=\u20090.272 per 100\u2009<jats:italic>\u03bc<\/jats:italic>m<jats:sup>2<\/jats:sup>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>). Of these, the parameter with the greatest AUC was the disc area (AUC\u2009=\u20090.79). Using the Youden index, the optimal cut-off point identified for stratification was a disc area greater than 2.33\u2009<jats:italic>\u03bc<\/jats:italic>m<jats:sup>2<\/jats:sup>. <jats:italic>Conclusions<\/jats:italic>. In patients with bilateral disc cupping, a decreased total RNFL thickness and smaller disc area seem to be associated with suprasellar tumors (when compared with open-angle glaucoma). These findings may aid in early diagnosis of cupping from suprasellar tumors, before compressive visual loss occurs.<\/jats:p>","DOI":"10.1155\/2019\/3564809","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T19:30:29Z","timestamp":1572377429000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-0993","authenticated-orcid":true,"given":"Michael","family":"Mimouni","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel"},{"name":"Technion\u2014Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Stiebel-Kalish","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel"},{"name":"Neuro-Ophthalmology Unit, Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Serov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Zbedat","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan D.","family":"Gaton","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"948","volume":"16","year":"1984","journal-title":"Annals of Ophthalmology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/wno.0000000000000289"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200208000-00002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-444-59602-4.00016-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2016.08.08"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.10.014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3129\/i09.080"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200306000-00013"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01977.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2427"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307730"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14766"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/3564809.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/3564809.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2019\/3564809.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T19:30:30Z","timestamp":1572377430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2019\/3564809\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":14,"alternative-id":["3564809","3564809"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3564809","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]}}}