{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:33Z","timestamp":1762102413541,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MH CZ\u2013DRO","award":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"],"award-info":[{"award-number":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"]}]},{"name":"MH CZ\u2013DRO","award":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"],"award-info":[{"award-number":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"]}]},{"name":"MH CZ\u2013DRO","award":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"],"award-info":[{"award-number":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"]}]},{"DOI":"10.13039\/501100001824","name":"Grant Agency of the Czech Republic","doi-asserted-by":"crossref","award":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"],"award-info":[{"award-number":["IGA_LF_2019_014","IGA_LF_2019_006","00098892","MZ CR VES15-28659A"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"<jats:p>Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc). To date, limited data on the cross-disease innate gene signature exists among those diseases. We compared therefore an innate gene signature of Toll-like receptors (TLRs), seven key members of the interleukin (IL)1\/IL1R family, and CXCL8\/IL8 in peripheral blood mononuclear cells from well-defined patients with active stages of RA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>36<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>DAS<\/mml:mtext><mml:mn>28<\/mml:mn><mml:mo>\u2265<\/mml:mo><mml:mn>3.2<\/mml:mn><\/mml:math>), SLE (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>28<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>SLEDAI<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math>), and SSc (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>22<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>revised<\/mml:mtext><mml:mtext>\u2009<\/mml:mtext><mml:mtext>EUSTAR<\/mml:mtext><mml:mtext>\u2009<\/mml:mtext><mml:mtext>index<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>2.25<\/mml:mn><\/mml:math>). Emerging diversity and abundance of the innate signature in RA patients were detected: RA was characterized by the upregulation of <jats:italic>TLR3<\/jats:italic>, <jats:italic>TLR5<\/jats:italic>, <jats:italic>IL1RAP\/IL1R3<\/jats:italic>, <jats:italic>IL18R1<\/jats:italic>, and <jats:italic>SIGIRR\/IL1R8<\/jats:italic> when compared to SSc (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>corr<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>&lt;<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) and of <jats:italic>TLR2<\/jats:italic>, <jats:italic>TLR5<\/jats:italic>, and <jats:italic>SIGIRR\/IL1R8<\/jats:italic> when compared to SLE (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>corr<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>&lt;<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>). Applying the association rule analysis, six rules (combinations and expression of genes describing disease) were identified for RA (most frequently included high <jats:italic>TLR3<\/jats:italic> and\/or <jats:italic>IL1RAP\/IL1R3<\/jats:italic>) and three rules for SLE (low <jats:italic>IL1RN<\/jats:italic> and <jats:italic>IL18R1<\/jats:italic>) and SSc (low <jats:italic>TLR5<\/jats:italic> and <jats:italic>IL18R1<\/jats:italic>). This first cross-disease study identified emerging heterogeneity in the innate signature of RA patients with many upregulated innate genes compared to that of SLE and SSc.<\/jats:p>","DOI":"10.1155\/2019\/3575803","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T19:30:49Z","timestamp":1563305449000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Cross-Disease Innate Gene Signature: Emerging Diversity and Abundance in RA Comparing to SLE and SSc"],"prefix":"10.1155","volume":"2019","author":[{"given":"Anna","family":"Petrackova","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Horak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III-Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Radvansky","sequence":"additional","affiliation":[{"name":"Faculty of Electrical Engineering and Computer Science, Department of Computer Science, VSB-Technical University of Ostrava, Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Skacelova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III-Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Fillerova","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Kudelka","sequence":"additional","affiliation":[{"name":"Faculty of Electrical Engineering and Computer Science, Department of Computer Science, VSB-Technical University of Ostrava, Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Smrzova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III-Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frantisek","family":"Mrazek","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-4197","authenticated-orcid":true,"given":"Eva","family":"Kriegova","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/j.jaci.2017.08.026"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.3389\/fimmu.2018.01702"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.4049\/jimmunol.1700332"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.3389\/fimmu.2017.02007"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1038\/nrrheum.2016.61"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1111\/imr.12621"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.febslet.2011.04.028"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.3389\/fphar.2014.00265"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1038\/aps.2015.91"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1111\/imr.12383"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1177\/1535370216681549"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1007\/s11926-014-0474-z"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1136\/ard.2010.138461"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1002\/art.1780400928"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1136\/annrheumdis-2013-204424"},{"volume":"37","year":"2019","journal-title":"Clinical and Experimental Rheumatology","key":"16"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1016\/j.joca.2014.08.004"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1186\/1756-0500-4-324"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1007\/978-3-319-62389-4_54"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1002\/wics.160"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1007\/s00217-017-2881-7"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.2307\/2528964"},{"key":"23","first-page":"1806","volume":"11","year":"2005","journal-title":"Journal of Universal Computer Science"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1002\/art.21273"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1002\/art.37992"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.1016\/j.autrev.2016.12.003"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.4049\/jimmunol.1102977"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.4049\/jimmunol.1302998"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1093\/rheumatology\/kew325"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1186\/s13075-015-0901-1"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1186\/s10020-018-0021-x"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1146\/annurev.immunol.021908.132612"},{"doi-asserted-by":"publisher","key":"36","DOI":"10.1172\/JCI32285"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1186\/s12864-015-1970-x"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1016\/j.procs.2015.03.177"},{"doi-asserted-by":"publisher","key":"39","DOI":"10.1002\/art.20219"},{"doi-asserted-by":"publisher","key":"40","DOI":"10.1136\/annrheumdis-2011-201203"},{"doi-asserted-by":"publisher","key":"41","DOI":"10.3389\/fimmu.2012.00366"},{"doi-asserted-by":"publisher","key":"42","DOI":"10.1080\/08916934.2017.1412431"},{"doi-asserted-by":"publisher","key":"43","DOI":"10.1007\/s10238-009-0036-2"},{"doi-asserted-by":"publisher","key":"44","DOI":"10.1002\/art.22707"},{"doi-asserted-by":"publisher","key":"45","DOI":"10.1073\/pnas.1410293111"},{"doi-asserted-by":"publisher","key":"46","DOI":"10.4049\/jimmunol.1502599"},{"key":"47","first-page":"5515","volume":"9","year":"2016","journal-title":"International Journal of Clinical and Experimental Pathology"},{"doi-asserted-by":"publisher","key":"48","DOI":"10.1002\/art.40535"},{"doi-asserted-by":"publisher","key":"49","DOI":"10.1093\/rheumatology\/kei244"},{"key":"50","first-page":"5","volume":"17","year":"2015","journal-title":"The Israel Medical Association Journal"},{"doi-asserted-by":"publisher","key":"51","DOI":"10.1001\/archderm.1994.01690100117021"},{"doi-asserted-by":"publisher","key":"52","DOI":"10.1111\/imr.12616"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3575803.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3575803.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/3575803.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T19:30:54Z","timestamp":1563305454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2019\/3575803\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,16]]},"references-count":49,"alternative-id":["3575803","3575803"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3575803","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2019,7,16]]}}}