{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:03:29Z","timestamp":1785881009802,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774317"],"award-info":[{"award-number":["81774317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,12,30]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Diabetic foot ulcer (DFU) is one of the most common complications of diabetes mellitus, with the wound not healing as expected and healing slowly. Poor control can develop into gangrene and even amputation. Currently, the existing treatments are not satisfactory enough. In China, KangFuXin liquid (KFXL) has been clinically used to treat DFU and has shown good clinical efficacy. In order to provide more reference to clinicians and experts, evidence of efficacy for it needs to be further rigorously evaluated. <jats:italic>Methods<\/jats:italic>. Eight electronic databases were searched to identify eligible randomized clinical trials (RCTs) published from construction of the library to April 2019. There is no language or data restriction; 11 trials involving 889 participants met the inclusion criteria. These RCTs compared the total effective rate, cure rate, cure time, and adverse events associated with KFXL. The Cochrane Handbook guidelines were used to assess the risk of bias and to evaluate the methodological quality of eligible studies. The methodological quality of included studies was generally low. Dichotomous and continuous data were presented using risk ratios (RRs) and mean differences (MDs), respectively. <jats:italic>Results<\/jats:italic>. Compared with the basic treatment, meta-analyses showed that KFXL combined with basic treatment can improve the total effective rate (RR\u2009=\u20091.38; 95% CI\u2009=\u20091.23\u20131.54; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>; fixed effect model: <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200932%) and cure rate (RR\u2009=\u20091.67; 95% CI\u2009=\u20091.17\u20132.38; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:mrow><\/mml:math>; random effect model: <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200965%), and shorten the healing time (MD\u2009=\u2009\u22125.73; 95% CI\u2009=\u2009\u22126.95 to \u22124.52; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>; random effect model). Moreover, under the same basic treatment, KFXL had a better effect than external use of pharmaceutical medications (RR\u2009=\u20091.95; 95% CI\u2009=\u20091.30\u20132.93; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), but the cure rate was not significantly different. Also, KFXL had nothing to do with adverse reactions. <jats:italic>Conclusion<\/jats:italic>. The evidence confirms that KFXL is an effective treatment for DFU. However, further large-scale, rigorously designed trials and high-quality studies are needed to confirm the role of KFXL in the treatment of DFU.<\/jats:p>","DOI":"10.1155\/2019\/3678714","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:30:59Z","timestamp":1577730659000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["KangFuXin Liquid in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-8611","authenticated-orcid":true,"given":"Ke Shen","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"},{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-6939","authenticated-orcid":true,"given":"Hua Fa","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"2017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0651"},{"key":"3","year":"2015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.007"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)67699-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/01.asw.0000436385.24508.d5"},{"key":"8","year":"1982"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-017-0149-6"},{"issue":"11","key":"10","first-page":"95","volume":"3","year":"2012","journal-title":"Medicinal Plant"},{"issue":"3","key":"11","first-page":"220","volume":"30","year":"2012","journal-title":"Chinese Journal of Industrial Hygiene and Occupational Diseases"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6019530"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3040"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.007"},{"key":"15","first-page":"18","volume":"18","year":"2017","journal-title":"Guangming Journal of Chinese Medicine"},{"key":"16","first-page":"159","volume":"16","year":"2016","journal-title":"Chinese Nursing Management"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"18","year":"2014"},{"key":"19","year":"2011"},{"issue":"2","key":"20","first-page":"50","volume":"17","year":"2010","journal-title":"Chinese Village Medicine"},{"issue":"5","key":"21","first-page":"636","volume":"45","year":"2016","journal-title":"Shaanxi Medical Journal"},{"issue":"10","key":"22","first-page":"136","volume":"33","year":"2018","journal-title":"Modern Medicine and Clinical"},{"issue":"1","key":"23","first-page":"40","volume":"25","year":"2011","journal-title":"Liao Ning Medical Journal"},{"issue":"4","key":"24","first-page":"141","volume":"17","year":"2019","journal-title":"Chinese and Foreign Medical Research"},{"issue":"5","key":"25","first-page":"26","volume":"19","year":"2010","journal-title":"Chinese Journal of External Therapy"},{"issue":"5","key":"26","first-page":"16","volume":"9","year":"2014","journal-title":"Chinese Practical Medicine"},{"issue":"19","key":"27","first-page":"1412","volume":"23","year":"2008","journal-title":"Clinical Gather"},{"key":"28","first-page":"52","volume":"26","year":"2015","journal-title":"Journal of Clinical Rational Drug Use"},{"key":"29","first-page":"265","volume":"35","year":"2014","journal-title":"Chinese Medicine Guide"},{"issue":"4","key":"30","first-page":"26","volume":"15","year":"2006","journal-title":"Chinese Journal of External Therapy"},{"key":"31","first-page":"294","volume":"36","year":"2015","journal-title":"Chemical Journal of Jinan University"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2046"},{"issue":"19","key":"33","first-page":"64","volume":"25","year":"2016","journal-title":"Chinese National Folk Medicine"},{"issue":"12","key":"34","first-page":"3028","volume":"23","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"2","key":"35","first-page":"125","volume":"37","year":"2015","journal-title":"Journal of Weifang Medical College"},{"issue":"22","key":"36","first-page":"145","volume":"22","year":"2016","journal-title":"Chinese Journal of Experimental Formulaology"},{"key":"37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/molecules23010101","volume":"23","year":"2018","journal-title":"Molecules"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2015.1047771"},{"issue":"6","key":"40","first-page":"445","volume":"42","year":"2019","journal-title":"Journal of Beijing University of Traditional Chinese Medicine"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/3678714.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/3678714.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/3678714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:31:23Z","timestamp":1577730683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/3678714\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":39,"alternative-id":["3678714","3678714"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3678714","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}