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Local brain function analysis methods included the amplitude of low-frequency fluctuation (ALFF). FC analysis methods consisted of the FC between the primary visual cortex (PVC-FC) and other brain regions and the FC network between regions of interest (ROIs-FC) selected by independent component analysis. <jats:italic>Results.<\/jats:italic> The ALFF in the bilateral frontal, temporal, and occipital lobes in the amblyopia group was lower than that in the HCs. The weakened PVC-FC was mainly concentrated in the frontal lobe and the angular gyrus. The ROIs-FC between the default mode network, salience network, and primary visual cortex network (PVCN) were significantly reduced, whereas the ROIs-FC between the PVCN and the high-level visual cortex network were significantly increased in amblyopia. <jats:italic>Conclusions.<\/jats:italic> Unilateral amblyopia may reduce local brain activity and FC in the dorsal and ventral visual pathways and affect the top-down attentional control. Amblyopia may also alter FC between brain functional networks. These findings may help understand the pathological mechanisms of children with amblyopia.<\/jats:p>","DOI":"10.1155\/2019\/3681430","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:31:17Z","timestamp":1564083077000},"page":"1-10","source":"Crossref","is-referenced-by-count":22,"title":["Altered Spontaneous Brain Activity of Children with Unilateral Amblyopia: A Resting State fMRI Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-2085","authenticated-orcid":true,"given":"Peishan","family":"Dai","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Central South University, Changsha, Hunan 410083, China"},{"name":"Hunan Engineering Research Center of Machine Vision and Intelligent Medicine, Central South University, Changsha 410083, 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